ArticleScience advances2022
Building block properties govern granular hydrogel mechanics through contact deformations.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Porcelain-clay-inspired microsphere hydrogel bioink facilitates bone regeneration via immune-osteogenic regulation.Bioactive materials · 2027Article
- Chondrogenic niche hydrogel microspheres facilitate cartilage regeneration in osteoarthritis.Bioactive materials · 2026Article
- Decoding Cytoskeletal Mechanobiology with Tunable Microenvironments.ACS biomaterials science & engineering · 2026Article
- Stress-Adaptive Biomaterials With Tunable Yielding Architectures Regulate Organoid Morphogenesis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Engineering Strain-Stiffening Granular Hydrogels for 3D-Printed Tissue-Mimicry.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Biohybrid cochlear implants: neural interfaces, regenerative pathways, and translational benchmarks.Journal of neuroengineering and rehabilitation · 2026Review
- Bioinstructive Orthogonally-crosslinked Ovoprotein Microgels for Modular Bioprinting.bioRxiv : the preprint server for biology · 2026Article
- Fiber-Based Hydrogels for Designing Viscoelastic Responses in Particle-Based Biomaterials That Support Embedded 3D Printing.ACS biomaterials science & engineering · 2026Article
- Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Emergent directional persistence in fibrous granular scaffolds guides myotube organization.bioRxiv : the preprint server for biology · 2026Article
- Adaptive PEG Bis-dendron Hydrogels with Tunable Mechanics and Bioactivity.Chemistry of materials : a publication of the American Chemical Society · 2026Article
- Reporter immunogenicity as a defined rejection antigen: a noninvasive platform for skin transplant immunobiology.Frontiers in immunology · 2026Article
- Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments.Advanced healthcare materials · 2025Review
- Granular Hydrogels as Brittle Yield Stress Fluids.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Particle-based hydrogel inks and support matrices for biofabricating structural complexity, soluble gradients, and cell-lined channels in fully granular bioprinted systems.Biofabrication · 2025Article
- High-Throughput Mechanical Characterization of Single Microgel Particles by Fluidic Force Microscopy.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Ultrahigh-Molecular-Weight Polymer Gels in Aqueous Media Using Cucurbit[8]uril-Assisted Radical Polymerization.Macromolecules · 2025Article
- Tuning the Morphological Properties of Granular Hydrogels to Control Lymphatic Capillary Formation.Advanced materials interfaces · 2025Article
- Cell-guiding microporous hydrogels by photopolymerization-induced phase separation.Nature communications · 2025Article
- Electrostatically Reinforced Double Network Granular Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Granular hydrogels have been increasingly exploited in biomedical applications, including wound healing and cardiac repair. Despite their utility, design guidelines for engineering their macroscale properties remain limited, as we do not understand how the properties of granular hydrogels emerge from collective interactions of their microgel building blocks. In this work, we related building block features (stiffness and size) to the macroscale properties of granular hydrogels using contact mechanics. We investigated the mechanics of the microgel packings through dynamic oscillatory rheology. In addition, we modeled the system as a collection of two-body interactions and applied the Zwanzig and Mountain formula to calculate the plateau modulus and viscosity of the granular hydrogels. The calculations agreed with the dynamic mechanical measurements and described how microgel properties and contact deformations define the rheology of granular hydrogels. These results support a rational design framework for improved engineering of this fascinating class of materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.