ArticlePLoS computational biology2022
Interacting active surfaces: A model for three-dimensional cell aggregates.
Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Biophysics of lumen morphogenesis.Development (Cambridge, England) · 2026Review
- Multicellular simulations with shape and volume constraints using optimal transport.Science advances · 2026Article
- Necking of epithelial tissues with cellular topological transition.PLoS computational biology · 2026Article
- From biting to engulfment: curvature-actin coupling controls phagocytosis of soft, deformable targets.bioRxiv : the preprint server for biology · 2026Article
- From biting to engulfment: curvature-actin coupling controls phagocytosis of soft, deformable targets.ArXiv · 2026Article
- A computational framework to study EGFR signaling distribution in egg chambers during dynamic interactions between soma and germline.PLoS computational biology · 2025Article
- Predicting organoid morphology through a phase field model: Insights into cell division and lumenal pressure.PLoS computational biology · 2025Article
- Article
- Vertex models capturing subcellular scales in epithelial tissues.PLoS computational biology · 2025Review
- The Mechanics of Building Functional Organs.Cold Spring Harbor perspectives in biology · 2025Review
- Article
- SimuCell3D: three-dimensional simulation of tissue mechanics with cell polarization.Nature computational science · 2024Article
- Semi-3D cultures using Laminin 221 as a coating material for human induced pluripotent stem cells.Regenerative biomaterials · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
We introduce a modelling and simulation framework for cell aggregates in three dimensions based on interacting active surfaces. Cell mechanics is captured by a physical description of the acto-myosin cortex that includes cortical flows, viscous forces, active tensions, and bending moments. Cells interact with each other via short-range forces capturing the effect of adhesion molecules. We discretise the model equations using a finite element method, and provide a parallel implementation in C++. We discuss examples of application of this framework to small and medium-sized aggregates: we consider the shape and dynamics of a cell doublet, a planar cell sheet, and a growing cell aggregate. This framework opens the door to the systematic exploration of the cell to tissue-scale mechanics of cell aggregates, which plays a key role in the morphogenesis of embryos and organoids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.