ArticleeLife2022
Lifespan extension in female mice by early, transient exposure to adult female olfactory cues.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Article
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- Perception and Longevity Control in Invertebrate Model Organisms-A Mini-Review of Recent Advances.Biomolecules · 2025Review
- Menopause-induced 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly and degeneration in mouse cartilage.Nature aging · 2025Article
- Anti-aging properties of the aminosterols of the dogfish shark.npj aging · 2024Review
- A mitochondrial unfolded protein response-independent role of DVE-1 in longevity regulation.Cell reports · 2024Article
- Early life interventions metformin and trodusquemine metabolically reprogram the developing mouse liver through transcriptomic alterations.Aging cell · 2024Article
- Early Life Interventions: Impact on Aging and Longevity.Aging and disease · 2024Review
- Exposure to female olfactory cues hastens reproductive ageing and increases mortality when mating in male mice.Proceedings. Biological sciences · 2024Article
- The neuropeptide drosulfakinin enhances choosiness and protects males from the aging effects of social perception.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Female scent accelerates growth of juvenile male mice.Scientific reports · 2023Article
- Sensory detection of female olfactory cues as a central regulator of energy metabolism and body weight in male mice.iScience · 2023Article
- A Year at the Forefront of Proteostasis and Aging.Biology open · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Several previous lines of research have suggested, indirectly, that mouse lifespan is particularly susceptible to endocrine or nutritional signals in the first few weeks of life, as tested by manipulations of litter size, growth hormone levels, or mutations with effects specifically on early-life growth rate. The pace of early development in mice can also be influenced by exposure of nursing and weanling mice to olfactory cues. In particular, odors of same-sex adult mice can in some circumstances delay maturation. We hypothesized that olfactory information might also have a sex-specific effect on lifespan, and we show here that the lifespan of female mice can be increased significantly by odors from adult females administered transiently, that is from 3 days until 60 days of age. Female lifespan was not modified by male odors, nor was male lifespan susceptible to odors from adults of either sex. Conditional deletion of the G protein Gαo in the olfactory system, which leads to impaired accessory olfactory system function and blunted reproductive priming responses to male odors in females, did not modify the effect of female odors on female lifespan. Our data provide support for the idea that very young mice are susceptible to influences that can have long-lasting effects on health maintenance in later life, and provide a potential example of lifespan extension by olfactory cues in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.