Evidence map›Paper›PMID 36525342›Full record

ArticleJournal of clinical laboratory analysis2023

Hematological characteristics of COVID-19 patients with fever infected by the Omicron variant in Shanghai: A retrospective cohort study in China.

Tingting Wei, Jiangyan Li, Zhuo Cheng, Liansheng Jiang, Jiafeng Zhang, Hao Wang, Lin Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tingting WeiDepartment of Laboratory Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-7796-0902
Jiangyan LiDepartment of Laboratory Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Zhuo ChengDepartment of Oncology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
Liansheng JiangDepartment of Laboratory Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Jiafeng ZhangDepartment of Laboratory Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Hao WangDepartment of Laboratory Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Lin ZhouDepartment of Laboratory Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-2549-2721
Shanghai Changzheng Hospital · CNSecond Military Medical University · CN

Funding

Foundation of Naval Medical University 2021QN37Leading Talents Program of Shanghai Huangpu District 2020-1-28National Natural Science Foundation of China 82072371National Natural Science Foundation of China 82202584
6 · The paper itself

Abstract

backgroundA wave of the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has rapidly spread in Shanghai, China. Hematological abnormalities have been reported in coronavirus disease 2019 (COVID-19) patients; however, the difference in hematological parameters between COVID-19 patients with fever and patients who are febrile from other causes remains unexplored.

methodsThis retrospective cohort study enrolled 663 SARS-CoV-2 positive patients identified by RT-PCR. Clinical parameters, including age, sex, and threshold cycle values of all COVID-19 patients, and hematological parameters of COVID-19 patients in the fever clinic were abstracted for analysis.

resultsOverall, 60.8% of COVID-19 patients were male, and the median age was 45 years. Most of COVID-19 patients were asymptomatic, while 25.8% of patients showed fever and 10.9% of patients had other emergencies. COVID-19 patients with fever had significantly lower white blood cells (WBCs), neutrophils, lymphocytes, platelets and C-reactive protein (CRP), and significantly higher monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), and mean platelet volume-to-platelet ratio (MPR) levels, compared with those in SARS-CoV-2 negative patients with fever from other causes (p < 0.05). Neutrophil-to-lymphocyte ratio (NLR), PLR, and systemic inflammatory index (SII) levels were significantly higher in COVID-19 patients with emergencies (p < 0.05). WBCs showed the best performance with an area under the curve (0.756), followed by neutrophils (0.730) and lymphocytes (0.694) in the diagnosis of COVID-19 in the fever clinic.

conclusionWBCs, neutrophils, lymphocytes, platelets, CRP and MLR, PLR, and MPR may be useful in early diagnosis of COVID-19 in the fever clinic.

Indexed as

COVID-19Blood PlateletsChinaC-Reactive ProteinEmergenciesFemaleHumansLymphocytesMaleMiddle AgedNeutrophilsRetrospective StudiesSARS-CoV-2C-Reactive Proteincoronavirus disease 2019differential diagnosishematological parametersinflammationsevere acute respiratory syndrome coronavirus 2

Identifiers

PMID36525342
PMCPMC9833982
OpenAlexW4311663897

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.