Evidence map›Paper›PMID 36525088›Full record

ArticleEuropean radiology2023

AI support for accurate and fast radiological diagnosis of COVID-19: an international multicenter, multivendor CT study.

Fanyang Meng, Jonathan Kottlors, Rahil Shahzad, Haifeng Liu, Philipp Fervers, Yinhua Jin, Miriam Rinneburger, Dou Le, Mathilda Weisthoff, Wenyun Liu and 15 more

Abstract readMulticenter Study
In one paragraph

Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Performance of AI Approaches for COVID-19 Diagnosis Using Chest CT Scans: The Impact of Architecture and Dataset.RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Fanyang MengDepartment of Radiology, The First Hospital of Ji Lin University, No. 1 Xinmin Street, Changchun, 130012, China.
Jonathan KottlorsInstitute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Rahil ShahzadInstitute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Haifeng LiuDepartment of Radiology, Wuhan No. 1 Hospital, Wuhan, China.
Philipp FerversInstitute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Yinhua JinDepartment of Radiology, Ningbo Hwamei Hospital, University of Chinese Academy of Sciences, Wuhan, China.
Miriam RinneburgerInstitute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Dou LeDepartment of Radiology, The First Hospital of Ji Lin University, No. 1 Xinmin Street, Changchun, 130012, China.
Mathilda WeisthoffInstitute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Wenyun LiuDepartment of Radiology, The First Hospital of Ji Lin University, No. 1 Xinmin Street, Changchun, 130012, China.
Mengzhe NiDepartment of Radiology, The First Hospital of Ji Lin University, No. 1 Xinmin Street, Changchun, 130012, China.
Ye SunDepartment of Radiology, The First Hospital of Ji Lin University, No. 1 Xinmin Street, Changchun, 130012, China.
Liying AnDepartment of Radiology, The First Hospital of Ji Lin University, No. 1 Xinmin Street, Changchun, 130012, China.
Xiaochen HuaiPhilips Healthcare, Beijing, China.
Dorottya MóréDepartment of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany.
Athanasios GiannakisDepartment of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany.
Isabel KaltenbornInstitute for Diagnostic and Interventional Radiology, Frankfurt University Hospital, Frankfurt, Germany.
Andreas BucherInstitute for Diagnostic and Interventional Radiology, Frankfurt University Hospital, Frankfurt, Germany.
David MaintzInstitute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Lei ZhangDepartment of Radiology, The First Hospital of Ji Lin University, No. 1 Xinmin Street, Changchun, 130012, China.
Frank ThieleInstitute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Mingyang LiDepartment of Radiology, The First Hospital of Ji Lin University, No. 1 Xinmin Street, Changchun, 130012, China.
Michael PerkuhnInstitute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Huimao ZhangDepartment of Radiology, The First Hospital of Ji Lin University, No. 1 Xinmin Street, Changchun, 130012, China. huimao@jlu.edu.cn.
Thorsten PersigehlInstitute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Funding

NIEHS NIH HHS 27398C0007
6 · The paper itself

Abstract

objectivesDifferentiation between COVID-19 and community-acquired pneumonia (CAP) in computed tomography (CT) is a task that can be performed by human radiologists and artificial intelligence (AI). The present study aims to (1) develop an AI algorithm for differentiating COVID-19 from CAP and (2) evaluate its performance. (3) Evaluate the benefit of using the AI result as assistance for radiological diagnosis and the impact on relevant parameters such as accuracy of the diagnosis, diagnostic time, and confidence.

methodsWe included n = 1591 multicenter, multivendor chest CT scans and divided them into AI training and validation datasets to develop an AI algorithm (n = 991 CT scans; n = 462 COVID-19, and n = 529 CAP) from three centers in China. An independent Chinese and German test dataset of n = 600 CT scans from six centers (COVID-19 / CAP; n = 300 each) was used to test the performance of eight blinded radiologists and the AI algorithm. A subtest dataset (180 CT scans; n = 90 each) was used to evaluate the radiologists' performance without and with AI assistance to quantify changes in diagnostic accuracy, reporting time, and diagnostic confidence.

resultsThe diagnostic accuracy of the AI algorithm in the Chinese-German test dataset was 76.5%. Without AI assistance, the eight radiologists' diagnostic accuracy was 79.1% and increased with AI assistance to 81.5%, going along with significantly shorter decision times and higher confidence scores.

conclusionThis large multicenter study demonstrates that AI assistance in CT-based differentiation of COVID-19 and CAP increases radiological performance with higher accuracy and specificity, faster diagnostic time, and improved diagnostic confidence. KEY POINTS: • AI can help radiologists to get higher diagnostic accuracy, make faster decisions, and improve diagnostic confidence. • The China-German multicenter study demonstrates the advantages of a human-machine interaction using AI in clinical radiology for diagnostic differentiation between COVID-19 and CAP in CT scans.

Indexed as

Community-Acquired InfectionsCOVID-19Deep LearningPneumoniaArtificial IntelligenceCOVID-19 TestingHumansSARS-CoV-2Tomography, X-Ray ComputedArtificial intelligenceComputed tomographyCOVID-19Radiologists

Identifiers

PMID36525088
PMCPMC9755771

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.