ArticleJournal of the American Chemical Society2022
Hydration in Deep Eutectic Solvents Induces Non-monotonic Changes in the Conformation and Stability of Proteins.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 95 citations in OpenAlex.
- Urea-Based Eutectic Mixtures as Green Plasticizers for Starch, Other Polysaccharides and Proteins.Molecules (Basel, Switzerland) · 2026Review
- Stability of Sodium Dodecyl Sulfate Micelles in Reline/Water Mixtures: A Molecular Dynamics Study.ACS omega · 2026Article
- Beyond Composition: Structure-Activity Relationships in Bioactive Deep Eutectic Systems.Pharmaceutics · 2026Review
- Stoichiometrically Engineered Hydrated Ionic Liquids Enabling Reinforcement of Enzyme Cascade with Improved Thermodynamic Stability.ACS sustainable chemistry & engineering · 2026Article
- Structural Properties of Coniferyl Alcohol-Based Low Transition Temperature Mixtures.ACS omega · 2026Article
- Study on the effects of media-regulated ultrasonic pretreatment combined with elwectrohydrodynamic drying on the drying kinetics, active components, proteomic characteristics and volatile components of garlic.Food chemistry: X · 2026Article
- Innovations in Platelet Cryopreservation: Evaluation of DMSO-Free Controlled-Rate Freezing and the Role of a Deep Eutectic Solvent as an Additional Cryoprotective Agent.International journal of molecular sciences · 2025Article
- Unravelling the influence of choline chloride-based deep eutectic solvents on lysozyme: a comparative study of fructose and formic acid donors.RSC advances · 2025Article
- Unlocking the full compositional control of hydrophilic and hydrophobic deep eutectic solvents over protein structure and stability.Communications chemistry · 2025Article
- Exploring the effect of natural deep eutectic solvents on zein: Structural and functional properties.Current research in food science · 2025Article
- Engineering enzyme conformation within liquid-solid hybrid microreactors for enhanced continuous-flow biocatalysis.Nature communications · 2024Article
- Understanding the Effect of Ionic Liquid-Mediated Solvent Engineering on the Kinetics and Thermodynamic Stability of Phenylalanine Ammonia-Lyase.The journal of physical chemistry. B · 2024Article
- Stabilization of Non-Native Folds and Programmable Protein Gelation in Compositionally Designed Deep Eutectic Solvents.ACS nano · 2024Article
- Harnessing the potential of deep eutectic solvents in biocatalysis: design strategies using COFrontiers in chemistry · 2024Article
- Rational design of deep eutectic solvents for the stabilization of dehydrogenases: an artificial neural network prediction approach.Frontiers in chemistry · 2024Article
- Hofmeister Effects Shine in Nanoscience.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- State-of-the-art and novel approaches to mild solubilization of inclusion bodies.Frontiers in bioengineering and biotechnology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The preservation of labile biomolecules presents a major challenge in chemistry, and deep eutectic solvents (DESs) have emerged as suitable environments for this purpose. However, how the hydration of DESs impacts the behavior of proteins is often neglected. Here, we demonstrate that the amino acid environment and secondary structure of two proteins (bovine serum albumin and lysozyme) and an antibody (immunoglobulin G) in 1:2 choline chloride:glycerol and 1:2 choline chloride:urea follow a re-entrant behavior with solvent hydration. A dome-shaped transition is observed with a folded or partially folded structure at very low (<10 wt % H
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.