Evidence map›Paper›PMID 36524701›Full record

ArticleHead & neck2023

Clinical outcomes of combined cervical and transthoracic surgical approaches in patients with advanced thyroid cancer.

Jared A Shenson, Mark E Zafereo, Mark Lee, Kevin J Contrera, Lei Feng, Mongkol Boonsripitayanon, Neil Gross, Ryan Goepfert, Anastasios Maniakas, Jennifer Rui Wang and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jared A ShensonDepartment of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-7751-7508
Mark E ZafereoDepartment of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Mark LeeDepartment of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Kevin J ContreraDepartment of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-2570-1706
Lei FengDepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Mongkol BoonsripitayanonDepartment of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Neil GrossDepartment of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-9427-0743
Ryan GoepfertDepartment of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-3291-841X
Anastasios ManiakasDepartment of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Jennifer Rui WangDepartment of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-0807-3832
Libby GrubbsDepartment of Surgical Oncology, Division of Endocrine Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Ara VaporciyanDepartment of Thoracic Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Wayne HofstetterDepartment of Thoracic Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Stephen SwisherDepartment of Thoracic Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Reza MehranDepartment of Thoracic Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
David RiceDepartment of Thoracic Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Boris SepesiDepartment of Thoracic Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Mara AntonoffDepartment of Thoracic Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Maria CabanillasDepartment of Medicine, Division of Endocrine Neoplasia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-5124-1811
Naifa BusaidyDepartment of Medicine, Division of Endocrine Neoplasia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Ramona DaduDepartment of Medicine, Division of Endocrine Neoplasia, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Natalie L SilverDepartment of Otolaryngology-Head & Neck Surgery, Cleveland Clinic, Cleveland, Ohio, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

backgroundAdvanced thyroid disease involving the mediastinum may be managed surgically with a combined transcervical and transthoracic approach. Contemporary analysis of this infrequently encountered cohort will aid the multidisciplinary team in personalizing treatment approaches.

methodsRetrospective review of patients undergoing combined transcervical and transthoracic surgery for thyroid cancer at a single high-volume institution from 1994 to 2015.

resultsThirty-eight patients with median age 59 years (range 28-76) underwent surgery without perioperative mortality. Most patients had primary disease. A majority had distant metastases outside the mediastinum but had locoregionally curable disease. Common complications were temporary (39%) and permanent (18%) hypoparathyroidism, and wound infection (13%). One-year overall survival was 84%; 1-year locoregional disease-free survival was 64%. Median time to locoregional recurrence was 36 months. Only esophageal invasion was associated with worse oncologic outcomes.

conclusionsCombined transcervical and transthoracic surgery for advanced thyroid cancer can be performed without mortality and with acceptable morbidity.

Indexed as

Thyroid DiseasesThyroid NeoplasmsAdultAgedHumansMiddle AgedNeckNeoplasm Recurrence, LocalRetrospective StudiesThyroidectomyadvanced thyroid cancerendocrine surgerymanubriectomyoutcomessternotomy

Identifiers

PMID36524701
PMCPMC12049177

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.