ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023
Peak Expiratory Flow Predicts Incident Dementia in a Representative Sample of U.S. Older Adults: The National Health and Aging Trends Study (NHATS).
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Purpose in life and lung function: an individual-participant meta-analysis of six cohort studies.Respiratory research · 2025Pooled it
- Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: unraveling the interplay with risk of dementia.Scientific reports · 2026Article
- Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: Unraveling the interplay with risk of dementia.Research square · 2025Article
- Peak Expiratory Flow and Its Trajectories Associated With Frailty in Older Adults: A Prospective Cohort Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- How much can biomarkers explain sociodemographic inequalities in cognitive dysfunction and cognitive impairment? Results from a machine learning model in the Health and Retirement Study.Journal of Alzheimer's disease : JAD · 2025Article
- Associations Between Peak Expiratory Flow and Community Mobility Loss Among Older Adults in the United States.Journal of the American Geriatrics Society · 2025Article
- Building Survey Data Infrastructure on Aging: The Legacy of NIA.The Gerontologist · 2025Article
- Peak expiratory flow predicts motoric cognitive risk syndrome: A cohort study.Journal of the American Geriatrics Society · 2025Article
- Association between pulmonary ventilation function and cognitive function among middle-aged and older adults: an observational study from Southwest China.BMC pulmonary medicine · 2024Observational
- Longitudinal Changes in Peak Expiratory Flow Predict Risk for Incident Dementia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Association between physical activity, peak expiratory flow, and cognitive function in aging: a cross-sectional analysis.BMC geriatrics · 2024Article
- Association of peak expiratory flow with motoric cognitive risk syndrome among older adults.Frontiers in aging neuroscience · 2024Article
- Serum-Creatinine-to-Cystatin C-to-Waist-Circumference Ratios as an Indicator of Severe Airflow Limitation in Older Adults.Journal of clinical medicine · 2023Article
- Population reference equations for handheld peak expiratory flow in older U.S. adults.Respiratory medicineArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDementia is an increasingly important public health problem with various risk factors. Respiratory function, measured via peak expiratory flow (PEF), may be a modifiable dementia risk factor.
methodsWe investigated the association between PEF and incident dementia in 5 935 older adults from the National Health and Aging Trends Study (NHATS) from 2011 to 2014. Baseline PEF, expressed as a standardized residual (SR) percentile, was analyzed as a predictor of incident dementia using discrete-time proportional hazards models, while controlling for several health and sociodemographic covariates.
resultsAfter 14 332 person-years of follow-up, 9.0% (N = 536) had incident cases of dementia. Compared to the lowest PEF category (SR-percentile < 10%), the highest PEF category (SR-percentile ≥ 80%) had 49% lower risk of incident dementia (hazard ratio [HR] = 0.51; 95% confidence interval [CI; 0.37, 0.71]), and the second highest PEF category (SR-percentile 50%-80%) had 25% lower risk of incident dementia (HR = 0.75; 95% CI [0.56, 1.00]). A sensitivity analysis using multiple imputation to account for missing PEF measurements yielded similar associations with incident dementia.
conclusionThese associations suggest a dose-dependent relationship such that higher PEF categories were more protective against incident dementia. PEF may be considered as an easily administered, low-cost measure of respiratory function and a potentially modifiable dementia risk factor. Improving PEF may reduce dementia risk through vascular mechanisms, such as increased brain oxygenation. Future research should explore potential causal pathways between PEF and dementia.
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