ArticleMicrocirculation (New York, N.Y. : 1994)2023
Comparison of laser speckle contrast imaging with laser Doppler perfusion imaging for tissue perfusion measurement.
Article in Microcirculation (New York, N.Y. : 1994), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Transplant international : official journal of the European Society for Organ Transplantation · 2024Pooled it
- Open-Label Interventional Study in Healthy Volunteers to Evaluate NO-Mediated Vasodilation by Dermal Allyl Isothiocyanate Challenge and Whole-Body Heat Stress.Journal of experimental pharmacology · 2024Trial
- Cold-induced vasomotion changes in healthy individuals and patients after median or ulnar nerve repair.Scientific reports · 2026Article
- Racial and Skin Tone Differences in Scar Maturation: A Prospective Analysis of Aesthetic and Physiological Outcomes Using the Modified POSAS Scale.International wound journal · 2026Observational
- Laser Doppler mapping of lower limb skin perfusion before and 5 h after exercise in warm conditions.Frontiers in physiology · 2026Article
- Cutaneous microcirculatory disturbances are reversible in the early post-resuscitation period after asphyxial cardiac arrest.Cardiovascular diagnosis and therapy · 2025Article
- A clinical research: blood perfusion of artificial dermis detected by laser speckle contrast imaging influence the therapeutic effect on wound healing.Lasers in medical science · 2025Article
- Early peripheral perfusion monitoring in septic shock.European journal of medical research · 2024Review
- A pilot study using the LASCA technique to analyze stress using heart rate variability.Lasers in medical science · 2024Article
- The impact of skin color and tone on histamine iontophoresis and Doppler flowmetry measurements as a pharmacodynamic biomarker.Clinical and translational science · 2024Observational
- Non-invasive medical imaging technology for the diagnosis of burn depth.International wound journal · 2024Review
- Comparison of laser speckle contrast imaging with laser Doppler perfusion imaging for tissue perfusion measurement.Microcirculation (New York, N.Y. : 1994) · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveLaser-based tissue perfusion monitoring techniques have been increasingly used in animal and human research to assess blood flow. However, these techniques use arbitrary units, and knowledge about their comparability is scarce. This study aimed to model the relationship between laser speckle contrast imaging (LSCI) and laser Doppler perfusion imaging (LDPI), for measuring tissue perfusion over a wide range of blood flux values.
methodsFifteen healthy volunteers (53% female, median age 29 [IQR 22-40] years) were enrolled in this study. We performed iontophoresis with sodium nitroprusside on the forearm to induce regional vasodilation to increase skin blood flux. Besides, a stepwise vascular occlusion was applied on the contralateral upper arm to reduce blood flux. Both techniques were compared using a linear mixed model analysis.
resultsBaseline blood flux values measured by LSCI were 33 ± 6.5 arbitrary unit (AU) (Coefficient of variation [CV] = 20%) and by LDPI 60 ± 11.5 AU (CV = 19%). At the end of the iontophoresis protocol, the regional blood flux increased to 724 ± 412% and 259 ± 87% of baseline measured by LDPI and LSCI, respectively. On the other hand, during the stepwise vascular occlusion test, the blood flux reduced to 212 ± 40% and 412 ± 177% of its baseline at LDPI and LSCI, respectively. A strong correlation was found between the LSCI and LDPI instruments at increased blood flux with respect to baseline skin blood flux; however, the correlation was weak at reduced blood flux with respect to baseline. DISCUSSION: LSCI and LDPI instruments are highly linear for blood flux higher than baseline skin blood flux; however, the correlation decreased for blood flux lower than baseline. This study's findings could be a basis for using LSCI in specific patient populations, such as burn care.
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Registered trials
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