Evidence map›Paper›PMID 36524248›Full record

ArticleNeuropsychopharmacology reports2023

The positive allosteric modulator of NMDA receptors, GNE-9278, blocks the ethanol-induced decrease of excitability in developing retrosplenial cortex neurons from mice.

Clark W Bird, Carlos F Valenzuela

Open access · goldAbstract read
In one paragraph

Article in Neuropsychopharmacology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. The positive allosteric modulator GNE-9278 increases gating, conductance, and CaNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Defects of Cortical Microcircuits Following Early Exposure to Alcohol.Advances in experimental medicine and biology · 2025
    Review
  3. Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Clark W BirdDepartment of Neurosciences, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.ORCID 0000-0001-7712-6531
Carlos F ValenzuelaDepartment of Neurosciences, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.ORCID 0000-0003-1026-9604
University of New Mexico · US

Funding

Alcohol and Developing Neuronal CircuitsR01AA015614 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Carlos Fernando Valenzuela · 2005 to 2026
$3.9M
NIAAA NIH HHS R01 AA015614
6 · The paper itself

Abstract

Binge-like exposure to ethanol during the brain growth spurt triggers apoptotic neurodegeneration in multiple brain regions, including the retrosplenial cortex, a brain region that is part of the hippocampal-diencephalic-cingulate memory network. This is mediated, in part, by reduced Ca

Indexed as

Central Nervous System DepressantsEthanolAnimalsBenzenesulfonamidesExcitatory Amino Acid AntagonistsGyrus CinguliMiceNeuronsN-MethylaspartatePyrimidinonesReceptors, N-Methyl-D-AspartateBenzenesulfonamidesCentral Nervous System DepressantsEthanolExcitatory Amino Acid AntagonistsGNE-9278N-MethylaspartatePyrimidinonesReceptors, N-Methyl-D-Aspartateallostericapoptosiscortexdevelopmentelectrophysiologyethanolfetalglutamateneonatalretrosplenial

Identifiers

PMID36524248
PMCPMC10009431
OpenAlexW4311667248

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.