Evidence map›Paper›PMID 36524209›Full record

ArticleOncoimmunology2022

Bystander CD4

Shamin Li, Summer Zhuang, Antja Heit, Si-Lin Koo, Aaron C Tan, I-Ting Chow, William W Kwok, Iain Beehuat Tan, Daniel S W Tan, Yannick Simoni and 1 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 55 citations in OpenAlex.

  1. CD39 on CD8European journal of immunology · 2026
    Review
  2. Cell surface ADGRG1 and CD86 expression identifies antitumor CD4Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Adaptive resistance in cancer immunotherapy.Cellular & molecular immunology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. A Framework for Comparing Mouse Neoantigen Immunogenicity.bioRxiv : the preprint server for biology · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. CD4Science immunology · 2024
    Article
  17. Article
  18. Review
  19. CD39 expression defines exhausted CD4Clinical & translational immunology · 2024
    Article
  20. Immune checkpoints are predominantly co-expressed by clonally expanded CD4Journal of experimental & clinical cancer research : CR · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Shamin LiFred Hutch Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington, USA.ORCID 0000-0001-7669-7391
Summer ZhuangFred Hutch Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington, USA.
Antja HeitFred Hutch Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington, USA.
Si-Lin KooDepartment of Anatomical Pathology, Singapore General Hospital, Singapore.
Aaron C TanDivision of Medical Oncology, National Cancer Centre Singapore (NCCS), Singapore, Singapore.
I-Ting ChowAgency for Science Technology and Research (AStar), Genome Institute of Singapore (GIS), Singapore, Singapore.
William W KwokAgency for Science Technology and Research (AStar), Genome Institute of Singapore (GIS), Singapore, Singapore.
Iain Beehuat TanDepartment of Anatomical Pathology, Singapore General Hospital, Singapore.
Daniel S W TanBenaroya Research Institute, Seattle, Washington, USA.
Yannick SimoniFred Hutch Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington, USA.ORCID 0000-0002-9086-3680
Evan W NewellFred Hutch Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington, USA.ORCID 0000-0002-2889-243X
Infectious Disease Research Institute · USAgency for Science, Technology and Research · SGSingapore General Hospital · SGBenaroya Research InstituteNational Cancer Centre Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8

Indexed as

CD8-Positive T-LymphocytesLung NeoplasmsHumansLymphocytes, Tumor-InfiltratingT-Lymphocytes, RegulatorybystandercancerCD39CD4CD8HCMVinfiltratingTILtumor

Identifiers

PMID36524209
PMCPMC9746624
OpenAlexW4225615463

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.