ReviewCureus2022
Thalassemia: A Review of the Challenges to the Families and Caregivers.
Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Pooled it
- The epidemiology of thalassaemia syndromes in Southeast Asia.The Lancet regional health. Southeast Asia · 2026Review
- Long-term survival rates of thalassemia patients following hematopoietic stem cell transplantation: A systematic review and meta-analysis.Hematology, transfusion and cell therapy · 2026Article
- Role of Family Dynamics in Shaping Coping Strategies Among Children with Transfusion-Dependent Thalassemia.Indian pediatrics · 2026Article
- Thalassemia in Guangxi: current situation and future prospects.Frontiers in public health · 2026Article
- Genetic Heterogeneity of β-thalassemia Variants in Affected Filipinos.Acta medica Philippina · 2026Article
- Direct and indirect medical costs associated with transfusion-dependent beta-thalassemia in Brazil, Thailand, and India.Therapeutic advances in hematology · 2026Article
- Explainable AI framework for improved Thalassemia mental health classification and feature selection.PloS one · 2026Article
- Characterization of oral microbiome alterations in thalassemia patients using 16S rRNA gene sequencing.Frontiers in microbiology · 2026Article
- A direct multiplex isothermal amplification-reverse dot blot hybridization system for β-thalassemia diagnosis.Annals of hematology · 2025Article
- Thalassemia dataset covering clinical, socioeconomic, and mental health aspects.Data in brief · 2025Article
- From misconceptions to empowerment: assessing health and genetic literacy on thalassemia among Tunisian secondary school students.BMC public health · 2025Article
- The direct costs of transfusion-dependent beta-thalassemia in Saudi Arabia: A cost of illness analysis study.Medicine · 2025Article
- Exploring the role of consanguinity in thalassemia prevalence in Pakistan: an in-depth analysis of genetic and cultural factors affecting public health.Annals of medicine and surgery (2012) · 2025Review
- Thalassemia in Sub-Saharan Africa: epidemiology, diagnosis, and management - a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Magnitude of Beta-Hemoglobinopathies through Biomarkers among the Selected Tribes of Dharmapuri, Tamil Nadu: A Community-Based Cross-Sectional Study.International journal of hematology-oncology and stem cell research · 2025Article
- Advancing CRISPR genome editing into gene therapy clinical trials: progress and future prospects.Expert reviews in molecular medicine · 2025Review
- Assessing knowledge on thalassemia for prevention and management practices among the tribal population of Sitteri Panchayat, Dharmapuri District, Tamil Nadu, India.Journal of family medicine and primary care · 2025Article
- Article
- CRISPR/Cas-edited iPSCs and mesenchymal stem cells: a concise review of their potential in thalassemia therapy.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thalassemias are a group of congenital hemoglobin (Hb) disorders distinguished by dwindling or total curtailment of production of one or more globin chains of hemoglobin tetramers, ensuing in unrestrained destruction of red blood cells (RBC) that causes severe anemia. The severity of the disease often remains immensely variable. Children with thalassemia suffer from the disease's consequences and treatment complications. The disease also causes a negative impact on family members, who suffer mentally, socially, financially, and even physically. In this review, we highlight the challenges experienced by the family and caregivers; for instance, repeated blood transfusion as the dominant origin of tissue casualty, morbidity, and fatal clinical outcomes. Treatment modalities regarding thalassemias were not successful until the inception of bone marrow transplantation and gene therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.