ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2022
MRI free water as a biomarker for cognitive performance: Validation in the MarkVCID consortium.
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Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 20 citations in OpenAlex.
- Effects of aerobic exercise and cardiorespiratory fitness on white matter free water fraction in older adults: a 1-year randomized controlled trial.GeroScience · 2026Trial
- Cerebral oxygen extraction fraction as a physiological biomarker in vascular cognitive impairment: A study in older adults enriched for small vessel diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cognitive reserve against vascular contributions to cognitive impairment and dementia: A scoping review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cortical free-water imaging in familial frontotemporal dementia associated with MAPT, GRN, and C9orf72 pathogenic variants.Research square · 2026Article
- MarkVCID2 Consortium for Clinical Validation of Biomarkers of Cerebral Small Vessel Disease: Validation Framework and Baseline Characteristics.Annals of neurology · 2026Article
- Vascular Cognitive Impairment and Dementia: Clinical Features, Neuropathology, and Biomarkers.Journal of the American College of Cardiology · 2026Review
- Explanatory limitations of CSF, plasma, and MRI biomarkers for inflammation and blood-brain barrier disruption in dementia.Frontiers in aging · 2026Article
- Association of MRI-Visible Perivascular Spaces with Early White Matter Injury.AJNR. American journal of neuroradiology · 2025Article
- Exosomal Non-Coding RNAs as Potential Biomarkers for Alzheimer's Disease: Advances and Perspectives in Translational Research.International journal of molecular sciences · 2025Review
- Glymphatic dysfunction associated with cortisol dysregulation in major depressive disorder.Translational psychiatry · 2025Article
- Assessing the Global Impact of Brain Small Vessel Disease on Cognition: The Multi-Ethnic Study of Atherosclerosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Multimodal Associations of Modifiable Risk Factors on White Matter Injury: The SOL-INCA-MRI Study (HCHS/SOL).Stroke · 2025Article
- Healthy dietary intake diminishes the effect of cerebral small vessel disease on cognitive performance in older adults.Frontiers in neurology · 2025Article
- Disentangling the contributions of cerebrovascular-related white matter integrity markers to cognitive aging.Cerebral circulation - cognition and behavior · 2025Article
- Free-water: A promising structural biomarker for cognitive decline in aging and mild cognitive impairment.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- MRI free water mediates the association between water exchange rate across the blood brain barrier and executive function among older adults.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Retinal perfusion is linked to cognition and brain MRI biomarkers in Black Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- National and international collaborations to advance research into vascular contributions to cognitive decline.Cerebral circulation - cognition and behavior · 2024Article
- STAREE-Mind Imaging Study: a randomised placebo-controlled trial of atorvastatin for prevention of cerebrovascular decline and neurodegeneration in older individuals.BMJ neurology open · 2023Article
- MRI free water as a biomarker for cognitive performance: Validation in the MarkVCID consortium.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
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Authors and funding
24 authors at 13 institutions in 1 country.
Pauline MaillardDepartment of Neurology University of California Davis California USA.
Laura J HillmerDepartment of Neurology University of New Mexico Albuquerque New Mexico USA.
Hanzhang LuDepartment of Radiology Johns Hopkins University School of Medicine Baltimore Maryland USA.
Konstantinos ArfanakisDepartment of Biomedical Engineering Illinois Institute of Technology Chicago Illinois USA.
Brian T GoldDepartment of Neuroscience University of Kentucky Lexington Kentucky USA.
Christopher E BauerDepartment of Neuroscience University of Kentucky Lexington Kentucky USA.
Joel H KramerDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco California USA.
Adam M StaffaroniDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco California USA.
Lara StablesDepartment of Neurology Memory and Aging Center Weill Institute for Neurosciences University of California San Francisco California USA.
Danny J J WangLaboratory of FMRI Technology (LOFT) Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California Los Angeles California USA.
Sudha SeshadriDepartment of Neurology Boston University School of Medicine Boston Massachusetts USA.
Claudia L SatizabalDepartment of Neurology Boston University School of Medicine Boston Massachusetts USA.
Alexa BeiserDepartment of Neurology Boston University School of Medicine Boston Massachusetts USA.
Mohamad HabesGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases University of Texas Health San Antonio San Antonio Texas USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine McGovern Medical School School of Public Health The University of Texas Health Science Center at Houston Houston Texas USA.
Thomas H MosleyMIND Center University of Mississippi Medical Center Jackson Mississippi USA.
Gary A RosenbergDepartment of Neurology University of New Mexico Albuquerque New Mexico USA.
Baljeet SinghDepartment of Neurology University of California Davis California USA.
Herpreet SinghDepartment of Neurology Massachusetts General Hospital Boston Massachusetts USA.
Kristin SchwabDepartment of Neurology Massachusetts General Hospital Boston Massachusetts USA.
Karl G HelmerDepartment of Radiology Harvard Medical School Boston Massachusetts USA.
Steven M GreenbergDepartment of Neurology Massachusetts General Hospital Boston Massachusetts USA.
Charles DeCarliDepartment of Neurology University of California Davis California USA.
Arvind CaprihanThe Mind Research Network Albuquerque New Mexico Albuquerque New Mexico USA.
Massachusetts General Hospital · USUniversity of California, Davis · USUniversity of California, San Francisco · USBoston University · USInstitute for Neurodegenerative Disorders · USUniversity of Kentucky · USUniversity of New Mexico · USJohns Hopkins University · USMind Research Network · USRush University Medical Center · USThe University of Texas Health Science Center at Houston · USUniversity of Mississippi Medical Center · USUniversity of Southern California · US
Funding
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7MUC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI JOHNSON, DAVID K · 1991 to 2020
$28.3MUC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2MSouth Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0MUniversity of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5MPRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MVCID Biomarkers Coordinating CenterU24NS100591 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Steven M Greenberg · 2016 to 2026
$19.8MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9MARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5MARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4MPilot Project Program (PPP)P30GM122734 · NIGMS · THE MIND RESEARCH NETWORK · PI MAYER, ANDREW ROBERT · 2018 to 2022
$7.0MNHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS R01 HL070825NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIA NIH HHS K23 AG061253NIA NIH HHS P20 AG068077NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072972NIA NIH HHS R01 AG052200NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG064233NIA NIH HHS R01 AG080821NIA NIH HHS RF1 AG059421NIA NIH HHS U01 AG052409NIBIB NIH HHS R01 EB028297NIGMS NIH HHS P30 GM122734NIH HHS S10 OD025313NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS114382NINDS NIH HHS T32 NS007412NINDS NIH HHS U01 NS100599NINDS NIH HHS U01 NS125513NINDS NIH HHS U24 NS100591NINDS NIH HHS UF1 NS100598NINDS NIH HHS UF1 NS100599NINDS NIH HHS UH2 NS100614NINDS NIH HHS UH3 NS100588NINDS NIH HHS UH3 NS100598NINDS NIH HHS UH3 NS100599NINDS NIH HHS UH3 NS100605NINDS NIH HHS UH3 NS100606NINDS NIH HHS UH3 NS100608NINDS NIH HHS UH3 NS100614
Abstract
Introduction: To evaluate the clinical validity of free water (FW), a diffusion tensor imaging-based biomarker kit proposed by the MarkVCID consortium, by investigating the association between mean FW (mFW) and executive function. Methods: Baseline mFW was related to a baseline composite measure of executive function (EFC), adjusting for relevant covariates, in three MarkVCID sub-cohorts, and replicated in five, large, independent legacy cohorts. In addition, we tested whether baseline mFW predicted accelerated EFC score decline (mean follow-up time: 1.29 years). Results: Higher mFW was found to be associated with lower EFC scores in MarkVCID legacy and sub-cohorts ( Discussion: mFW is a sensitive biomarker of cognitive decline, providing a strong clinical rational for its use as a marker of white matter (WM) injury in multi-site observational studies and clinical trials of vascular cognitive impairment and dementia (VCID).
Indexed as
biomarkerdiffusion tensor imagingfree watersmall vessel diseasevascular contributions to cognitive impairment and dementiaVCIDwhite matter injury
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