Evidence map›Paper›PMID 36523699›Full record

ReviewCureus2022

Association Between Diabetes and Immunoglobulin M Antibodies Against Endogenous Gonadotropin-Releasing Hormone in Serum: A Meta-Analysis.

Amine Rakab, Karam R Motawea, Samah S Rozan, Hagar Mahmoud Hamouda, Haidar Alibrahim, Nesreen Elsayed Talat, Rowan Elhalag, Bisher Sawaf, Gihan Mohamed, Adel Albozom and 4 more

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 5 countries.

Amine RakabDepartment of Medical Education, Weill Cornell Medicine Hospital, Doha, QAT.
Karam R MotaweaFaculty of Medicine, Alexandria University, Alexandria, EGY.
Samah S RozanFaculty of Medicine, Alexandria University, Alexandria, EGY.
Hagar Mahmoud HamoudaFaculty of Medicine, Alexandria University, Alexandria, EGY.
Haidar AlibrahimFaculty of Medicine, Aleppo University, Aleppo, SYR.
Nesreen Elsayed TalatFaculty of Medicine, Alexandria University, Alexandria, EGY.
Rowan ElhalagFaculty of Medicine, Alexandria University, Alexandria, EGY.
Bisher SawafDepartment of Internal Medicine, Hamad Medical Corporation Hospital, Doha, QAT.
Gihan MohamedDepartment of Internal Medicine, Hamad Medical Corporation Hospital, Doha, QAT.
Adel AlbozomDepartment of Internal Medicine, Hamad Medical Corporation Hospital, Doha, QAT.
Sarya SwedFaculty of Medicine, Aleppo University, Aleppo, SYR.
Hesham Mohamed AbuelsaoudDepartment of Internal Medicine, National Medical Commission Royal Hospital, Abu Dhabi, ARE.
Rehab Mohamed ElshazlyFaculty of Medicine, Ain Shams University, Cairo, EGY.
Wael HafezDepartment of Internal Medicine, The National Research Centre, Cairo, EGY.
Alexandria University · EGHamad Medical Corporation · QAUniversity of Aleppo · SYAin Shams University · EGNational Research Centre · EGRoyal Commission Medical Center · SAWeill Cornell Medical College in Qatar · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our aim was to perform a meta-analysis to evaluate the possible link between diabetes and high levels of immunoglobulin M (IgM) antibodies against Gonadotropin-Releasing Hormone (GnRH). The search included PubMed, Web of Science, and Scopus databases. Inclusion criteria were any controlled clinical trials or observational studies that measured the level of IgM antibodies against GnRH hormone in diabetic patients, we excluded case reports, editorials, and animal studies. RevMan software, version 5.4 (The Cochrane Collaboration 2020) was used to perform the meta-analysis. Following the screening, three studies were included in the meta-analysis. The meta-analysis included 99 patients in the diabetes group and 318 healthy persons in the control group. The pooled effect showed no statistically significant association between diabetes and the prevalence of GnRH IgM antibodies compared with the control group (risk ratio {RR} = 1.64, 95% CI = 0.96 to 2.79, p-value = 0.03). The pooled effect showed a statistically significant association between diabetes and increased levels of GnRH IgM antibodies compared with the control group (mean difference {MD} = 2.13, 95% CI = 0.25 to 4.02, p-value = 0.03). Our study found a significant association between diabetes and increased levels of GnRH IgM antibodies. Therefore, GnRH IgM antibodies may play a role in the pathogenesis of diabetes or may be considered a unique immunological reaction in diabetic patients. More multicenter randomized studies are needed to support our results confirming the positive relationship between diabetes and high levels of IgM antibodies against GnRH hormone.

Indexed as

diabetes mellitusendogenous gonadotropin-releasing hormonegnrh igm antibodiesigm antibodiesmeta-analysis

Identifiers

PMID36523699
PMCPMC9744356
OpenAlexW4309084223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.