Evidence map›Paper›PMID 36523691›Full record

ArticleCureus2022

Antineutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis With Mucosal Involvement Following COVID-19 Pneumonia.

Hoang Ta, Hussein Awada, Puneet Kang, Nathaniel Gilbert, Nairmeen Haller, Eliot Mostow, Jason Lane, Inderprit Singh

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. COVID-19 and Glomerular Diseases.Kidney international reports · 2023
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hoang TaInternal Medicine, Cleveland Clinic Akron General, Akron, USA.
Hussein AwadaInternal Medicine, Cleveland Clinic Akron General, Akron, USA.
Puneet KangInternal Medicine, University Hospitals Cleveland Medical Center, Cleveland, USA.
Nathaniel GilbertInternal Medicine, Cleveland Clinic Akron General, Akron, USA.
Nairmeen HallerResearch, Cleveland Clinic Akron General, Akron, USA.
Eliot MostowDermatology, Cleveland Clinic Akron General, Akron, USA.
Jason LanePathology, Cleveland Clinic Akron General, Akron, USA.
Inderprit SinghRheumatology, Cleveland Clinic Akron General, Akron, USA.
Cleveland Clinic · USAkron General Medical Center · USUniversity Hospitals of Cleveland · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are a group of inflammatory disorders in which autoantibodies damage small arteries throughout the body, including in the upper and lower respiratory system, kidneys, as well as the skin. AAV may be precipitated by a variety of causes, including infections. In this report, we examine the case of a patient who developed AAV that was suspected primarily based on mucocutaneous hemorrhagic bullae, elevated ANCA levels, and subsequently confirmed by kidney biopsy, while recovering from coronavirus disease 2019 (COVID-19) infection. AAV and COVID-19 infections may present with similar symptoms, rendering an accurate diagnosis challenging. Additionally, only a few other cases describing a similar onset of AAV post-COVID-19 infection have been described in the literature. Initial presenting features of AAV in such cases have varied considerably, which makes the diagnosis even more challenging. We also engage in a review of such cases to assess key similarities, different treatment options, and outcomes. Lastly, the fact that several mechanisms have been proposed for AAV highlights the need for continued research to help clarify the pathophysiology while also identifying the optimal therapy.

Indexed as

anca-associated vasculitideshemorrhagic bullaeleukocytoclastic vasculitisneutrophil extracellular trapspauci-immune necrotizing crescentic glomerulonephritispost-covid-19 inflammatory responsesuperantigens

Identifiers

PMID36523691
PMCPMC9746658
OpenAlexW4309043436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.