ArticleRadiology. Artificial intelligence2022
Automated Classification of Intramedullary Spinal Cord Tumors and Inflammatory Demyelinating Lesions Using Deep Learning.
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Article in Radiology. Artificial intelligence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
–field-weighted citation impact
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Who cites it
15 citing papers in PubMed.
- Radiomics and machine learning for differentiating pediatric intramedullary spinal tumors: a pilot study.European radiology experimental · 2026Article
- Current Applications of Artificial Intelligence in Neuro-Ophthalmic Imaging: A Narrative Approach.Medical sciences (Basel, Switzerland) · 2026Review
- Current Trends and Future Prospects of Radiomics and Machine Learning (ML) Models in Spinal Tumors-A Narrative Review.Journal of imaging · 2026Review
- Development and validation of a multi-modal MRI-based deep learning framework for differentiation of intraspinal tumors (ISMF-Net).EClinicalMedicine · 2025Article
- Evaluation of a deep learning segmentation tool to help detect spinal cord lesions from combined T2 and STIR acquisitions in people with multiple sclerosis.European radiology · 2025Article
- Artificial intelligence and machine learning in spine care: Advancing precision diagnosis, treatment, and rehabilitation.World journal of orthopedics · 2025Review
- Current imaging applications, radiomics, and machine learning modalities of CNS demyelinating disorders and its mimickers.Journal of neurology · 2025Review
- Fractal-Based Architectures with Skip Connections and Attention Mechanism for Improved Segmentation of MS Lesions in Cervical Spinal Cord.Diagnostics (Basel, Switzerland) · 2025Article
- Assessing the effectiveness of machine learning and deep learning in differentiating neuroimmunological diseases: a systematic review and meta-analysis.Frontiers in neurology · 2025Article
- Applications of Artificial Intelligence and Machine Learning in Spine MRI.Bioengineering (Basel, Switzerland) · 2024Review
- Quantification of cervical spinal stenosis by automated 3D MRI segmentation of spinal cord and cerebrospinal fluid space.Spinal cord · 2024Article
- Article
- Exemplar MobileNetV2-Based Artificial Intelligence for Robust and Accurate Diagnosis of Multiple Sclerosis.Diagnostics (Basel, Switzerland) · 2023Article
- AI in MRI: Computational Frameworks for a Faster, Optimized, and Automated Imaging Workflow.Bioengineering (Basel, Switzerland) · 2023Article
- Current Applications of Machine Learning for Spinal Cord Tumors.Life (Basel, Switzerland) · 2023Review
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Authors and funding
21 authors.
Zhizheng Zhuo *Department of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).
Jie Zhang *Department of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).
Yunyun DuanDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).
Liying QuDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).
Chenlu FengDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).
Xufang HuangDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).
Dan ChengDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).ORCID 0000-0002-0555-3275
Xiaolu XuDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).ORCID 0000-0001-9963-529X
Ting SunDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).ORCID 0000-0003-4324-4024
Zhaohui LiDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).
Xiaopeng GuoDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).ORCID 0000-0002-9805-1409
Xiaodong GongDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).ORCID 0000-0002-8567-0411
Yongzhi WangDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).
Wenqing JiaDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).
Decai TianDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).ORCID 0000-0002-5153-2491
Xinghu ZhangDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).
Fudong ShiDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).
Sven HallerDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).ORCID 0000-0001-7433-0203
Frederik BarkhofDepartment of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).ORCID 0000-0003-3543-3706
Chuyang Ye *Department of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).ORCID 0000-0001-5839-1559
Yaou Liu *Department of Radiology (Z.Z., J.Z., Y.D., L.Q., C.F., X.H., D.C., X.X., T.S., Y.L.), Department of Neurosurgery (Y.W., W.J.), and Center for Neurology (D.T., X.Z., F.S.), Beijing Tiantan Hospital, Capital Medical University, No. 119, West Southern 4th Ring Road, Fengtai District, Beijing 100070, People's Republic of China; BioMind, Beijing, People's Republic of China (Z.L.); Department of Medical Imaging Product, Neusoft Group, Shenyang, People's Republic of China (X. Guo, X. Gong); China National Clinical Research Center for Neurologic Diseases, Beijing, People's Republic of China (D.T., F.S.); Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, People's Republic of China (F.S.); Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); UCL Institutes of Neurology and Healthcare Engineering, London, England (F.B.); Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, the Netherlands (F.B.); and School of Information and Electronics, Beijing Institute of Technology, Beijing, People's Republic of China (C.Y.).ORCID 0000-0002-9930-0331
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurate differentiation of intramedullary spinal cord tumors and inflammatory demyelinating lesions and their subtypes are warranted because of their overlapping characteristics at MRI but with different treatments and prognosis. The authors aimed to develop a pipeline for spinal cord lesion segmentation and classification using two-dimensional MultiResUNet and DenseNet121 networks based on T2-weighted images. A retrospective cohort of 490 patients (118 patients with astrocytoma, 130 with ependymoma, 101 with multiple sclerosis [MS], and 141 with neuromyelitis optica spectrum disorders [NMOSD]) was used for model development, and a prospective cohort of 157 patients (34 patients with astrocytoma, 45 with ependymoma, 33 with MS, and 45 with NMOSD) was used for model testing. In the test cohort, the model achieved Dice scores of 0.77, 0.80, 0.50, and 0.58 for segmentation of astrocytoma, ependymoma, MS, and NMOSD, respectively, against manual labeling. Accuracies of 96% (area under the receiver operating characteristic curve [AUC], 0.99), 82% (AUC, 0.90), and 79% (AUC, 0.85) were achieved for the classifications of tumor versus demyelinating lesion, astrocytoma versus ependymoma, and MS versus NMOSD, respectively. In a subset of radiologically difficult cases, the classifier showed an accuracy of 79%-95% (AUC, 0.78-0.97). The established deep learning pipeline for segmentation and classification of spinal cord lesions can support an accurate radiologic diagnosis.
Indexed as
AstrocytomaDeep LearningEpendymomaMultiple SclerosisNeuromyelitis Optica Spectrum DisorderSpinal Cord MRI
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