Evidence map›Paper›PMID 36523555›Full record

ArticleFrontiers in physiology2022

Skeletal muscle metabolism and contraction performance regulation by teneurin C-terminal-associated peptide-1.

David W Hogg, Andrea L Reid, Thomas L Dodsworth, Yani Chen, Ross M Reid, Mei Xu, Mia Husic, Peggy R Biga, Andrew Slee, Leslie T Buck and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

David W HoggDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Andrea L ReidDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Thomas L DodsworthDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Yani ChenDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Ross M ReidDepartment of Biology, University of Alabama, Birmingham, AL, United States.
Mei XuDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Mia HusicDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Peggy R BigaDepartment of Biology, University of Alabama, Birmingham, AL, United States.
Andrew SleeProtagenic Therapeutics, Inc., Lexington, MA, United States.
Leslie T BuckDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Dalia Barsyte-LovejoyStructural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Marius Locke5 Department of Kinesiology, University of Toronto, Toronto, ON, Canada.
David A LovejoyDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
University of Toronto · CAUniversity of Alabama at Birmingham · USStructural Genomics Consortium · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle regulation is responsible for voluntary muscular movement in vertebrates. The genes of two essential proteins, teneurins and latrophilins (LPHN), evolving in ancestors of multicellular animals form a ligand-receptor pair, and are now shown to be required for skeletal muscle function. Teneurins possess a bioactive peptide, termed the teneurin C-terminal associated peptide (TCAP) that interacts with the LPHNs to regulate skeletal muscle contractility strength and fatigue by an insulin-independent glucose importation mechanism in rats. CRISPR-based knockouts and siRNA-associated knockdowns of LPHN-1 and-3 in the C2C12 mouse skeletal cell line shows that TCAP stimulates an LPHN-dependent cytosolic Ca

Indexed as

ATPcalciumCRISPRenergyevolutionlatrophilinmitochondriateneurin

Identifiers

PMID36523555
PMCPMC9745124
OpenAlexW4310988715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.