Evidence map›Paper›PMID 36523261›Full record

ArticleVeterinary surgery : VS2023

Experimental models of bone marrow lesions in ovine femoral condyles.

Holly L Stewart, Jeremiah T Easley, Kurt T Selberg, Christian M Puttlitz, Lucas K Nakamura, Jimmy W Johnson, Christopher E Kawcak

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary surgery : VS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Holly L StewartDepartment of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.ORCID https://orcid.org/0000-0002-8655-8069
Jeremiah T EasleyDepartment of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Kurt T SelbergEnvironmental & Radiological Health Sciences Department, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Christian M PuttlitzDepartment of Mechanical Engineering, Colorado State University, Fort Collins, Colorado, USA.
Lucas K NakamuraDepartment of Mechanical Engineering, Colorado State University, Fort Collins, Colorado, USA.
Jimmy W JohnsonDepartment of Mechanical Engineering, Colorado State University, Fort Collins, Colorado, USA.
Christopher E KawcakDepartment of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Colorado State University · US

Funding

American College of Veterinary Surgeons Foundation Zoetis Dual Training GrantColorado State University Research Council of the College of Veterinary Medicine and Biomedical Sciences
6 · The paper itself

Abstract

objectiveTo develop an in vivo experimental model for bone marrow lesions (BMLs) in ovine femorotibial joints. STUDY

designRandomized, prospective experimental study. ANIMALS: Eighteen healthy, skeletally-mature Dorper cross ewes.

methodsOne medial femoral condyle was penetrated with a 1.1 mm pin, and the contralateral medial femoral condyle was treated with transcutaneous extracorporeal shockwave (ESW) at 0.39 ± 0.04 mJ/mm

resultsPin penetration induced a BML detected on MRI within 2 weeks and lasted at least 12 weeks. BMLs were not observed in ESW-treated condyles. Histologically, BMLs were characterized by hemorrhage and inflammatory cellular infiltrate, and progressed to more dense fibrous tissue over time. Pathological changes were not observed in the articular cartilage overlying the region of BMLs.

conclusionsDirect, focal trauma to all layers of the osteochondral unit was sufficient to create an experimentally-induced BML which persisted for at least 90 days. The protocol used for ESW in this study did not induce BMLs. CLINICAL SIGNIFICANCE: Experimental induction of BMLs is possible and mimicked naturally occurring disease states. Volumetric imaging is a sensitive method for characterization of the dynamic nature of these lesions.

Indexed as

Bone DiseasesCartilage, ArticularCartilage DiseasesOsteoarthritis, KneeSheep DiseasesAnimalsBone MarrowFemaleFemurKnee JointMagnetic Resonance ImagingModels, TheoreticalProspective StudiesSheepSheep, Domestic

Identifiers

PMID36523261
PMCPMC10108275
OpenAlexW4311677682

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.