Evidence map›Paper›PMID 36522849›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023

Blood-brain barrier disruption measured by albumin index correlates with inflammatory fluid biomarkers.

Laura Hillmer, Erik B Erhardt, Arvind Caprihan, John C Adair, Janice E Knoefel, Jill Prestopnik, Jeffrey Thompson, Sasha Hobson, Gary A Rosenberg

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  14. Effect of equine-derivedFrontiers in microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Laura HillmerCenter for Memory and Aging, University of New Mexico, Albuquerque, New Mexico.
Erik B ErhardtDepartment of Mathematics and Statistics, University of New Mexico, Albuquerque, New Mexico.
Arvind CaprihanThe Mind Research Network, Albuquerque, New Mexico.
John C AdairCenter for Memory and Aging, University of New Mexico, Albuquerque, New Mexico.
Janice E KnoefelCenter for Memory and Aging, University of New Mexico, Albuquerque, New Mexico.
Jill PrestopnikCenter for Memory and Aging, University of New Mexico, Albuquerque, New Mexico.
Jeffrey ThompsonCenter for Memory and Aging, University of New Mexico, Albuquerque, New Mexico.
Sasha HobsonCenter for Memory and Aging, University of New Mexico, Albuquerque, New Mexico.
Gary A RosenbergCenter for Memory and Aging, University of New Mexico, Albuquerque, New Mexico.
University of New Mexico · USMind Research Network · US

Funding

UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
Research Education ComponentP30AG086404 · NIA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Gary Allen Rosenberg · 2024 to 2026
$17.7M
Validation of Biomarkers of Small Vessel Injury in VCIDUF1NS100598 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2021 to 2023
$6.3M
Pathobiology of Vascular Cognitive ImpairmentR01NS052305 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2006 to 2016
$4.3M
MRI and CSF Biomarkers of White Matter Injury in VCIDUH3NS100598 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2018 to 2020
$3.3M
Scientific CoreP20AG068077 · NIA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2020 to 2022
$3.1M
Siemens MAGNETOM Prisma/Prisma fit upgradeS10OD025313 · OD · THE MIND RESEARCH NETWORK · PI MAYER, ANDREW ROBERT · 2018 to 2018
$1.5M
NCATS NIH HHS UL1 TR001449NIA NIH HHS P20 AG068077NIA NIH HHS P30 AG086404NIH HHS S10 OD025313NINDS NIH HHS R01 NS052305NINDS NIH HHS UF1 NS100598NINDS NIH HHS UH3 NS100598
6 · The paper itself

Abstract

Blood-brain barrier (BBB) permeability can be measured by the ratio of albumin in cerebrospinal fluid (CSF) and blood and by dynamic contrast-enhanced MRI (DCEMRI). Albumin is a large molecule measured in CSF and blood to form the albumin index (Q

Indexed as

AlbuminsBlood-Brain BarrierBiomarkersCytokinesHumansInflammationAlbuminsBiomarkersCytokinesalbumin indexBlood-brain barrierdynamic contrast-enhanced MRIinflammationpermeability

Identifiers

PMID36522849
PMCPMC10108191
OpenAlexW4311665860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.