ArticleBMC medicine2022
Association of shift work with incident dementia: a community-based cohort study.
Article in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Role of Life's Essential 8 in the association of night shift work with cardiovascular disease and mortality: a prospective cohort study of UK Biobank participants.Journal of global health · 2026Article
- Circadian Rhythm Disorder-Related Dysfunctions are Exacerbated by Aging and Ameliorated by Time-Restricted Feeding.Neuroscience bulletin · 2026Article
- Diurnal variation in neurovascular coupling and the impact of sleep quality: a UK Biobank study.Sleep · 2026Article
- Protocol for a systematic review and meta-analysis on the associations between short rest periods between shifts and health, function, and behavioral outcomes.Systematic reviews · 2026Article
- Article
- Associations between serum lipid profiles and the incidence of chronic obstructive pulmonary disease in the UK Biobank.Journal of health, population, and nutrition · 2025Article
- Social determinants of dementia: A scoping review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- BioClocks UK: driving robust cycles of discovery to impact.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Re-Evaluating Recommended Optimal Sleep Duration: A Perspective on Sleep Literacy.Children (Basel, Switzerland) · 2024Review
- Association of sleep duration with excess risk of dementia among shift workers in the UK biobank: a population-based cohort study.Journal of neurology · 2024Article
- Associations between long-term night shift work and incidence of chronic obstructive pulmonary disease: a prospective cohort study of 277,059 UK Biobank participants.BMC medicine · 2024Article
- Quantifying Personalized Shift-Work Molecular Portraits Underlying Alzheimer's Disease through Computational Biology.The journal of prevention of Alzheimer's disease · 2024Article
- Work-related factors and risk of amyotrophic lateral sclerosis: A multivariable Mendelian randomization study.Brain and behavior · 2023Article
- Lifestyle Factors in the Association of Shift Work and Depression and Anxiety.JAMA network open · 2023Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSome observational studies had found that shift work would increase risks of metabolic disorders, cancers, and cardiovascular diseases, but there was no homogeneous evidence of such an association between shift work and incident dementia. This study aimed to investigate whether shift work would increase the risk of dementia in a general population.
methodsOne hundred seventy thousand seven hundred twenty-two employed participants without cognitive impairment or dementia at baseline recruited between 2006 and 2010 were selected from the UK Biobank cohort study. Follow-up occurred through June 2021. Shift work status at baseline was self-reported by participants and they were categorized as non-shift workers or shift workers. Among shift workers, participants were further categorized as night shift workers or shift but non-night shift workers. The primary outcome was all-cause dementia in a time-to-event analysis, and the secondary outcomes were subtypes of dementia, including Alzheimer's disease, vascular dementia, and other types of dementia.
resultsIn total, 716 dementia cases were observed among 170,722 participants over a median follow-up period of 12.4 years. Shift workers had an increased risk of all-cause dementia as compared with non-shift workers after multivariable adjustment (hazard ratio [HR], 1.30, 95% confidence interval [CI], 1.08-1.58); however, among shift workers, night shift work was not associated with the risk of dementia (HR, 1.04, 95% CI, 0.73-1.47). We found no significant interaction between shift work and genetic predisposition to dementia on the primary outcome (P for interaction = 0.77).
conclusionsShift work at baseline was associated with an increased risk of all-cause dementia. Among shift workers, there was no significant association between night shift work and the risk of dementia. The increased incidence of dementia in shift workers did not differ between participants in different genetic risk strata for dementia.
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