ReviewFluids and barriers of the CNS2022
Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies.
Review in Fluids and barriers of the CNS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 77 citations in OpenAlex.
- Quantitative assessment of flow between cerebrospinal and interstitial fluid compartments in humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mechanistic multiphysics modeling reveals how blood pulsation drives CSF flow, pressure, and brain deformation under physiological and injection conditions.Fluids and barriers of the CNS · 2026Article
- Quantifying cerebrospinal fluid flow in pial perivascular spaces of rats.Fluids and barriers of the CNS · 2026Article
- Variability in the circulation of cerebrospinal fluid: causes and clinical implications for intraventricular drug delivery.Frontiers in drug delivery · 2026Review
- Targeting angiopoietin like-2 positive senescent cells improves cognitive impairment in adult male but not female atherosclerotic LDLrGeroScience · 2025Article
- Indirect Deuterium Displacement Exchange Imaging for Noninvasive High-Resolution CSF Production Mapping.bioRxiv : the preprint server for biology · 2025Article
- Human deep sleep facilitates cerebrospinal fluid dynamics linked to spontaneous brain oscillations and neural events.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Assessing morphological changes in the choroid plexus between standing and supine positions using a rotatable MRI system.Scientific reports · 2025Article
- CSF transport at the brain-meningeal border: effects on neurological health and disease.The Lancet. Neurology · 2025Review
- The Cerebrospinal Fluid Secretion Rate Increases in Awake and Freely Moving Rats but Differs With Experimental Methodology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Arterial pulsations and transmantle pressure synergetically drive glymphatic flow.Scientific reports · 2025Article
- Assessing the feasibility of a new approach to measure the full spectrum of cerebrospinal fluid dynamics within the human brain using MRI: insights from a simulation study.Interface focus · 2025Article
- VIEshunt: towards a ventricular intelligent and electromechanical shunt for hydrocephalus therapy.Fluids and barriers of the CNS · 2025Article
- Quantitative evaluation of normal cerebrospinal fluid flow in Sylvian aqueduct and perivascular spaces of middle cerebral artery and circle of Willis using 2D phase-contrast MRI imaging.Frontiers in neuroscience · 2025Article
- A case of brain abscess successfully treated with continuous irrigation therapy.Surgical neurology international · 2025Article
- Quantitative assessment of brain glymphatic imaging features using deep learning-based EPVS segmentation and DTI-ALPS analysis in Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- CSF production rate, resistance to reabsorption, and intracranial pressure: a systematic review and meta-analysis.Brain communications · 2025Review
- Synthetic peptide V11A reduces bacterial load and inflammation in pneumococcal meningitis.Frontiers in cellular and infection microbiology · 2025Article
- Quantitative and qualitative investigation of shunt failure in anFrontiers in bioengineering and biotechnology · 2025Article
- Relaxation-exchange magnetic resonance imaging (REXI): a non-invasive imaging method for evaluating trans-barrier water exchange in the choroid plexus.Fluids and barriers of the CNS · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
Cerebrospinal fluid (CSF) is an essential and critical component of the central nervous system (CNS). According to the concept of the "third circulation" originally proposed by Cushing, CSF is mainly produced by the choroid plexus and subsequently leaves the cerebral ventricles via the foramen of Magendie and Luschka. CSF then fills the subarachnoid space from whence it disperses to all parts of the CNS, including the forebrain and spinal cord. CSF provides buoyancy to the submerged brain, thus protecting it against mechanical injury. CSF is also transported via the glymphatic pathway to reach deep interstitial brain regions along perivascular channels; this CSF clearance pathway promotes transport of energy metabolites and signaling molecules, and the clearance of metabolic waste. In particular, CSF is now intensively studied as a carrier for the removal of proteins implicated in neurodegeneration, such as amyloid-β and tau. Despite this key function of CSF, there is little information about its production rate, the factors controlling CSF production, and the impact of diseases on CSF flux. Therefore, we consider it to be a matter of paramount importance to quantify better the rate of CSF production, thereby obtaining a better understanding of CSF dynamics. To this end, we now review the existing methods developed to measure CSF production, including invasive, noninvasive, direct, and indirect methods, and MRI-based techniques. Depending on the methodology, estimates of CSF production rates in a given species can extend over a ten-fold range. Throughout this review, we interrogate the technical details of CSF measurement methods and discuss the consequences of minor experimental modifications on estimates of production rate. Our aim is to highlight the gaps in our knowledge and inspire the development of more accurate, reproducible, and less invasive techniques for quantitation of CSF production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.