Evidence map›Paper›PMID 36522582›Full record

ArticleGlycoconjugate journal2023

The lectin DrfL inhibits cell migration, adhesion and triggers autophagy-dependent cell death in glioma cells.

Ingrid A V Wolin, Ana Paula M Nascimento, Rodrigo Seeger, Gabriela G Poluceno, Alfeu Zanotto-Filho, Claudia B Nedel, Carla I Tasca, Sarah Elizabeth Gomes Correia, Messias Vital Oliveira, Vanir Reis Pinto-Junior and 4 more

RetractedAbstract readRetracted Publication
PubMed Publisher
In one paragraph

Article in Glycoconjugate journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Ingrid A V WolinDepartamento de Bioquímica e Programa de Pós-Graduação em Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Florianópolis, Santa Catarina, 88040-900, Brazil.
Ana Paula M NascimentoDepartamento de Bioquímica e Programa de Pós-Graduação em Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Florianópolis, Santa Catarina, 88040-900, Brazil.
Rodrigo SeegerDepartamento de Bioquímica e Programa de Pós-Graduação em Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Florianópolis, Santa Catarina, 88040-900, Brazil.
Gabriela G PolucenoDepartamento de Bioquímica e Programa de Pós-Graduação em Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Florianópolis, Santa Catarina, 88040-900, Brazil.
Alfeu Zanotto-FilhoDepartamento de Farmacologia e Programa de Pós-Graduação em Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Florianópolis, Santa Catarina, 88040-900, Brazil.
Claudia B NedelDepartamento de Biologia Celular, Embriologia e Genética, Programa Pós-Graduação em Biologia Celular e do Desenvolvimento, Universidade Federal de Santa Catarina, Campus Universitário, Florianópolis, Santa Catarina, 88040-900, Brazil.
Carla I TascaDepartamento de Bioquímica e Programa de Pós-Graduação em Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Florianópolis, Santa Catarina, 88040-900, Brazil.
Sarah Elizabeth Gomes CorreiaDepartamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, CEP, 60020-181, BioMolLab, Fortaleza, Ceará, Brazil.
Messias Vital OliveiraDepartamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, CEP, 60020-181, BioMolLab, Fortaleza, Ceará, Brazil.
Vanir Reis Pinto-JuniorDepartamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, CEP, 60020-181, BioMolLab, Fortaleza, Ceará, Brazil.
Vinicius Jose Silva OsterneDepartamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, CEP, 60020-181, BioMolLab, Fortaleza, Ceará, Brazil.
Kyria Santiago NascimentoDepartamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, CEP, 60020-181, BioMolLab, Fortaleza, Ceará, Brazil.
Benildo Sousa CavadaDepartamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, CEP, 60020-181, BioMolLab, Fortaleza, Ceará, Brazil.
Rodrigo Bainy LealDepartamento de Bioquímica e Programa de Pós-Graduação em Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário, Florianópolis, Santa Catarina, 88040-900, Brazil. rbleal@gmail.com.ORCID http://orcid.org/0000-0003-2536-6888
Universidade Federal de Santa Catarina · BRUniversidade Federal do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is the most aggressive type of glioma, displaying atypical glycosylation pattern that may modulate signaling pathways involved in tumorigenesis. Lectins are glycan binding proteins with antitumor properties. The present study was designed to evaluate the antitumor capacity of the Dioclea reflexa lectin (DrfL) on glioma cell cultures. Our results demonstrated that DrfL induced morphological changes and cytotoxic effects in glioma cell cultures of C6, U-87MG and GBM1 cell lines. The action of DrfL was dependent upon interaction with glycans, and required a carbohydrate recognition domain (CRD), and the cytotoxic effect was apparently selective for tumor cells, not altering viability and morphology of primary astrocytes. DrfL inhibited tumor cell migration, adhesion, proliferation and survival, and these effects were accompanied by activation of p38

Indexed as

Antineoplastic AgentsAutophagic Cell DeathDiocleaGliomaApoptosisAutophagyCaspase 8Cell Line, TumorCell MovementCell ProliferationHumansLectinsProto-Oncogene Proteins c-aktAntineoplastic AgentsCaspase 8LectinsProto-Oncogene Proteins c-aktCancerCell signalingTumor-sphere

Identifiers

PMID36522582
OpenAlexW4311675604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.