ArticleScientific reports2022
Myopia: why the retina stops inhibiting eye growth.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 58 citations in OpenAlex.
- Time outdoors prevents myopia in hyperopic children, but protection is weaker in premyopic children: a post-hoc analysis of a cluster-randomised trial.The British journal of ophthalmology · 2026Trial
- Cross-tissue dual-omics analysis reveals molecular programs linked to myopia susceptibility and progression.Life science alliance · 2026Article
- Mesopic Illumination in Natural Environments: Implications for Myopia Research.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Short-Term Effects of Optically Induced and Digitally Simulated Myopic Blur on Retinal Perfusion: Insights From Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2026Article
- Focusing on color: How the eye chooses which wavelength to see best.Science advances · 2026Article
- S-Cone Retinal Pathway Dysfunction in Myopia.Investigative ophthalmology & visual science · 2026Article
- Review
- Short-Term Changes in Retinal Activity With Four Myopia Control Spectacle Lenses.Translational vision science & technology · 2026Article
- The Potential of Self-Controlled Focus for Myopia Prevention: A Pilot Study Using a Mobile Phone.Translational vision science & technology · 2026Article
- Light and myopia: a focus on the expanding role of non-visual opsins.Eye and vision (London, England) · 2026Review
- Interaction Between Near Work and Narrowband Light on Choroidal Thickness.Investigative ophthalmology & visual science · 2026Article
- One-Year Efficacy and Tolerance of Myofix Defocus Spectacles for Control of Myopia Progression.Ophthalmology and therapy · 2026Article
- Role of light in eye growth and light as a therapy for myopia control.Frontiers in ophthalmology · 2026Review
- Roadmap on advances in visual and physiological optics.Journal of optics (2010) · 2025Review
- IMI: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies.Investigative ophthalmology & visual science · 2025Review
- The role of astigmatism in myopia development, myopia progression and myopia control.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Review
- Acceleration of Myopic Shifts in Refraction and Axial Elongation Begins in the Premyopia Stage.Investigative ophthalmology & visual science · 2025Article
- Methylphenidate Inhibits the Development of Myopia by Altering Dopamine and Norepinephrine Reuptake.Investigative ophthalmology & visual science · 2025Article
- Nonlinear spatial integration allows the retina to detect the sign of defocus in natural scenes.Science advances · 2025Article
- Optical and Visual Diet in Myopia.Investigative ophthalmology & visual science · 2025Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In myopia, the eye grows too long, and the image projected on the retina is poorly focused when subjects look at a distance. While the retina normally controls eye growth by visual processing, it seems to give up during myopia development. But what has changed? To determine whether the sharp image is in front or behind the retinal plane, a comparison of image sharpness in red and blue would provide a reliable cue because focal planes are about 1.3 D apart due to longitudinal chromatic aberration (LCA). However, up to now, it could not be demonstrated that the retina does, in fact, such a comparison. We used a new approach: movies were digitally filtered in real time to present either the blue channel of the RGB color format unfiltered while green and red were blurred ("blue in focus"), or the red channel was unfiltered while green and blue were blurred ("red in focus") accordingly to the human LCA function. Here we show that, even though filtered movies looked similar, eyes became significantly shorter when the movie was sharp in the red plane but became longer when it was presented sharp in the blue plane. Strikingly, the eyes of young subjects who were already myopic did not respond at all-showing that their retina could no longer decode the sign of defocus based on LCA. Our findings resolve a long-standing question as to how the human retina detects the sign of defocus. It also suggests a new non-invasive strategy to inhibit early myopia development: keeping the red image plane on a computer screen sharp but low pass filtering the blue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.