ArticleCommunications biology2022
Neural complexity is a common denominator of human consciousness across diverse regimes of cortical dynamics.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- High-order brain interactions in ketamine during rest and task: a double-blinded cross-over design using portable EEG on male participants.Translational psychiatry · 2024Trial
- Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Observational
- Anesthetic State-Dependent Bidirectional Control of States of Consciousness via Heterogeneous Medial Septum to Ventral Tegmental Area Circuits under Sevoflurane in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Adversarial AI reveals mechanisms and treatments for disorders of consciousness.Nature neuroscience · 2026Article
- Illuminating consciousness.Frontiers in psychology · 2026Review
- Markers of consciousness in infants: Towards a 'cluster-based' approach.Acta paediatrica (Oslo, Norway : 1992) · 2025Review
- Entropy and Complexity Tools Across Scales in Neuroscience: A Review.Entropy (Basel, Switzerland) · 2025Review
- Complex network behavior in epileptic patients treated with Vagus Nerve Stimulation (VNS): VNS responders exhibit a unique pattern, different from VNS non-responders and healthy controls.Frontiers in neuroscience · 2025Article
- High-order brain interactions in ketamine during rest and task: A double-blinded cross-over design using portable EEG.Research square · 2024Article
- Carving Nature at Its Joints: A Comparison of CEMI Field Theory with Integrated Information Theory and Global Workspace Theory.Entropy (Basel, Switzerland) · 2023Article
- Paradoxical pharmacological dissociations result from drugs that enhance delta oscillations but preserve consciousness.Communications biology · 2023Review
- Editorial: Dissociations between neural activity and conscious state: a key to understanding consciousness.Frontiers in human neuroscience · 2023Article
- From early to contemporary normative modeling: Mapping individual differences in neurophysiological signals.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
What is the common denominator of consciousness across divergent regimes of cortical dynamics? Does consciousness show itself in decibels or in bits? To address these questions, we introduce a testbed for evaluating electroencephalogram (EEG) biomarkers of consciousness using dissociations between neural oscillations and consciousness caused by rare genetic disorders. Children with Angelman syndrome (AS) exhibit sleep-like neural dynamics during wakefulness. Conversely, children with duplication 15q11.2-13.1 syndrome (Dup15q) exhibit wake-like neural dynamics during non-rapid eye movement (NREM) sleep. To identify highly generalizable biomarkers of consciousness, we trained regularized logistic regression classifiers on EEG data from wakefulness and NREM sleep in children with AS using both entropy measures of neural complexity and spectral (i.e., neural oscillatory) EEG features. For each set of features, we then validated these classifiers using EEG from neurotypical (NT) children and abnormal EEGs from children with Dup15q. Our results show that the classification performance of entropy-based EEG biomarkers of conscious state is not upper-bounded by that of spectral EEG features, which are outperformed by entropy features. Entropy-based biomarkers of consciousness may thus be highly adaptable and should be investigated further in situations where spectral EEG features have shown limited success, such as detecting covert consciousness or anesthesia awareness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.