Evidence map›Paper›PMID 36522332›Full record

ArticleNPJ Parkinson's disease2022

Incidence of Parkinson disease in North America.

A W Willis, E Roberts, J C Beck, B Fiske, W Ross, R Savica, S K Van Den Eeden, C M Tanner, C Marras, Parkinson’s Foundation P4 Group

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06899022 (Investigating the Role of Attention in Perceptual and Cognitive Consequences of Parkinson's Disease), which is not on this map. Cited by 192 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
192citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06899022 narecruitingnot on this mapstarted 2025, after this paper: background citation

Investigating the Role of Attention in Perceptual and Cognitive Consequences of Parkinson's Disease

TypeinterventionalSponsorUniversity of NebraskaRan2025 to 2028Enrolled138ConditionsEssential Tremor, Parkinson&#39, s Disease (PD), DystoniasArmsNormal therapeutic DBS, Reduced current DBS, Reduced frequency DBS
3 · Its place in the literature

Who cites it

192 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
  2. Detection of parkinson's disease with neuroimaging modalities using machine learning and artificial intelligence: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  15. Extreme heat and hospitalization with Parkinson's disease among older adults.Journal of exposure science & environmental epidemiology · 2026
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132 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

A W WillisUniversity of Pennsylvania, Philadelphia, PA, USA. Allison.willis2@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-5724-7192
E RobertsVerge Genomics, San Francisco, CA, USA.
J C BeckParkinson's Foundation, Miami, FL, USA.ORCID http://orcid.org/0000-0002-4884-9893
B FiskeMichael J. Fox Foundation, New York, NY, USA.ORCID http://orcid.org/0000-0002-8797-2042
W RossPacific Health Research and Education Institute, Honolulu, HI, USA.
R SavicaMayo Clinic, Rochester, MN, USA.
S K Van Den EedenKaiser Permanente Northern California, Oakland, CA, USA.ORCID http://orcid.org/0000-0002-5599-8387
C M TannerUniversity of California at San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3775-5082
C MarrasUniversity of Toronto, Toronto, CA, USA.
Parkinson’s Foundation P4 Group

Funding

Midcareer Development Award in Neuroaging and Geriatric Pharmacoepidemiology ResearchK24AG075234 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Allison Willis · 2022 to 2026
$808k
NIA NIH HHS K24 AG075234
6 · The paper itself

Abstract

Parkinson disease (PD) is the second most common age-related neurodegenerative condition diagnosed in North America. We recently demonstrated, using multiple epidemiological data sources, that the prevalence of PD diagnoses was greater than previously reported and currently used for clinical, research, and policy decision-making. Prior PD incidence estimates have varied, for unclear reasons. There is a need for improved estimates of PD incidence, not only for care delivery planning and future policy but also for increasing our understanding of disease risk. The objective of this study was thus to investigate the incidence of Parkinson disease across five epidemiological cohorts in North America in a common year, 2012. The cohorts contained data on 6.7 million person-years of adults ages 45 and older, and 9.3 million person-years of adults ages 65 and older. Our estimates of age-sex-adjusted incidence of PD ranged from 108 to 212 per 100,000 among persons ages 65 and older, and from 47 to 77 per 100,00 among persons ages 45 and older. PD incidence increased with age and was higher among males. We also found persistent spatial clustering of incident PD diagnoses in the U.S. PD incidence estimates varied across our data sources, in part due to case ascertainment and diagnosis methods, but also possibly due to the influence of population factors (prevalence of genetic risk factors or protective markers) and geographic location (exposure to environmental toxins). Understanding the source of these variations will be important for health care policy, research, and care planning.

Identifiers

PMID36522332
PMCPMC9755252

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.