Evidence map›Paper›PMID 36522158›Full record

ReviewNeurology2023

Microembolism and Other Links Between Migraine and Stroke: Clinical and Pathophysiologic Update.

Simona Sacco, Andrea M Harriott, Cenk Ayata, Raffaele Ornello, Rodrigo Bagur, Amado Jimenez-Ruiz, Luciano A Sposato

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PubMed Full text at PMC Publisher
In one paragraph

Review in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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  12. Investigation of the subclinical atherosclerosis risk in patients with migraine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Simona SaccoFrom the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada.ORCID 0000-0003-0651-1939
Andrea M HarriottFrom the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada.
Cenk AyataFrom the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada.
Raffaele OrnelloFrom the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada.ORCID 0000-0001-9501-4031
Rodrigo BagurFrom the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada.ORCID 0000-0003-1888-9429
Amado Jimenez-RuizFrom the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada.ORCID 0000-0002-0257-3107
Luciano A SposatoFrom the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada. lucianosposato@gmail.com.ORCID 0000-0001-6425-9343
Western University · CA

Funding

Sex Differences in the Role of Gonadal Hormones and the Hypothalamus in Migraine with Aura.K08NS124991 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Andrea M Harriott · 2022 to 2026
$1.1M
NINDS NIH HHS K08 NS124991
6 · The paper itself

Abstract

Migraine and stroke are highly prevalent diseases with a high effect on quality of life, with multiple epidemiologic, pathophysiologic, clinical, and prognostic areas of overlap. Migraine is a risk factor for stroke. This risk is explained by common risk factors, migraine-specific mechanisms, and non-migraine-specific mechanisms that have a relevant role in patients with migraine with aura (e.g., atrial fibrillation and paradoxical embolism through a patent foramen ovale). Another important link between migraine aura and ischemic stroke is cardiac embolism. Cardioembolism is the most frequent cause of ischemic stroke, and increasing evidence suggests that microembolism, predominantly but not exclusively originating in the heart, is a contributing mechanism to the development of migraine aura. In this review, we discuss epidemiologic aspects of the association between migraine and ischemic stroke, the clinical presentation of ischemic strokes in patients with migraine, and the differentiation between migrainous and nonmigrainous infarctions. After that, we review migraine-specific and non-migraine-specific stroke mechanisms. We then review updated preclinical and clinical data on microembolism as a cause of migraine aura. In the last section, we summarize knowledge gaps and important areas to explore in future research. The review includes a clinical vignette with a discussion of the most relevant topics addressed.

Indexed as

EpilepsyForamen Ovale, PatentIschemic StrokeMigraine DisordersMigraine with AuraStrokeHumansQuality of Life

Identifiers

PMID36522158
PMCPMC10103117
OpenAlexW4311677799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.