Evidence map›Paper›PMID 36522129›Full record

ArticleGenes & development

Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs.

Lara Bideyan, Maykel López Rodríguez, Christina Priest, John P Kennelly, Yajing Gao, Alessandra Ferrari, Prashant Rajbhandari, An-Chieh Feng, Sergei G Tevosian, Stephen T Smale and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lara BideyanDepartment of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, USA.ORCID 0000-0001-8749-6464
Maykel López RodríguezDepartment of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, USA.
Christina PriestDepartment of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, USA.
John P KennellyDepartment of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, USA.
Yajing GaoDepartment of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, USA.
Alessandra FerrariDepartment of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, USA.
Prashant RajbhandariDepartment of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, USA.
An-Chieh FengDepartment of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, USA.
Sergei G TevosianDepartment of Physiological Sciences, University of Florida, Gainesville, Florida 32610, USA.
Stephen T SmaleDepartment of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, USA.
Peter TontonozDepartment of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, USA.ORCID 0000-0003-1259-0477
University of California, Los Angeles · USUniversity of Florida · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
NCI NIH HHS P30 CA016042
6 · The paper itself

Abstract

GATA4 is a transcription factor known for its crucial role in the development of many tissues, including the liver; however, its role in adult liver metabolism is unknown. Here, using high-throughput sequencing technologies, we identified GATA4 as a transcriptional regulator of metabolism in the liver. GATA4 expression is elevated in response to refeeding, and its occupancy is increased at enhancers of genes linked to fatty acid and lipoprotein metabolism. Knocking out GATA4 in the adult liver (Gata4LKO) decreased transcriptional activity at GATA4 binding sites, especially during feeding. Gata4LKO mice have reduced plasma HDL cholesterol and increased liver triglyceride levels. The expression of a panel of GATA4 binding genes involved in hepatic cholesterol export and triglyceride hydrolysis was down-regulated in Gata4LKO mice. We further demonstrate that GATA4 collaborates with LXR nuclear receptors in the liver. GATA4 and LXRs share a number of binding sites, and GATA4 was required for the full transcriptional response to LXR activation. Collectively, these results show that hepatic GATA4 contributes to the transcriptional control of hepatic and systemic lipid homeostasis.

Indexed as

LiverOrphan Nuclear ReceptorsAnimalsCholesterolGATA4 Transcription FactorHomeostasisLipid MetabolismLiver X ReceptorsMiceMice, Inbred C57BLTriglyceridesCholesterolGata4 protein, mouseGATA4 Transcription FactorLiver X ReceptorsOrphan Nuclear ReceptorsTriglycerideslipid metabolismLXRtranscription factor

Identifiers

PMID36522129
PMCPMC9851399
OpenAlexW4311666826

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.