Evidence map›Paper›PMID 36521924›Full record

ArticleThe Journal of rheumatology2023

Predicting Disease Activity in Rheumatoid Arthritis With the Fibromyalgia Survey Questionnaire: Does the Severity of Fibromyalgia Symptoms Matter?

Alexander M Gorzewski, Andrew C Heisler, Tuhina Neogi, Lutfiyya N Muhammad, Jing Song, Dorothy Dunlop, Clifton O Bingham, Marcy B Bolster, Daniel J Clauw, Wendy Marder and 1 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of rheumatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Guideline
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Alexander M GorzewskiA.M. Gorzewski, BA, Northwestern University, Chicago, Illinois.ORCID 0000-0002-0657-1328
Andrew C HeislerA.C. Heisler, MD, MSci, Rheumatology, Department of Medicine, Western Michigan University, Kalamazoo, Michigan.ORCID 0000-0003-3718-3886
Tuhina NeogiT. Neogi, MD, PhD, Department of Rheumatology, Boston University School of Medicine, Boston, Massachusetts.ORCID 0000-0002-9515-1711
Lutfiyya N MuhammadL.N. Muhammad, PhD, J. Song, MS, Department of Preventive Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0001-8655-1484
Jing SongL.N. Muhammad, PhD, J. Song, MS, Department of Preventive Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0002-8881-9664
Dorothy DunlopD. Dunlop, PhD, Department of Medicine, Northwestern University, Chicago, Illinois.ORCID 0000-0002-7226-3956
Clifton O BinghamC.O. Bingham III, MD, Johns Hopkins Arthritis Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-4752-5029
Marcy B BolsterM.B. Bolster, MD, Division of Rheumatology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0002-5413-9345
Daniel J ClauwD.J. Clauw, MD, Rheumatology, Department of Medicine and Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-8114-7818
Wendy MarderW. Marder, MD, Rheumatology, Department of Medicine, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0001-7963-4206
Yvonne C LeeY.C. Lee, MD, MMSc, Rheumatology, Department of Medicine, Northwestern University, Chicago, Illinois, USA. yvonne.lee@northwestern.edu.ORCID 0000-0002-2105-3393
Northwestern University · USUniversity of Michigan · USBoston University · USJohns Hopkins University · USMassachusetts General Hospital · USWestern Michigan University · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Sample Processing and Immunoassay Research CoreP30AR070254 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CLIFTON O BINGHAM, Antony Rosen · 2016 to 2026
$8.9M
Resource CoreP30AR072579 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NAN E ROTHROCK · 2017 to 2026
$8.3M
Northwestern University Clinical and Translational Science Institute (NUCATS)KL2TR001424 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHARMA, LEENA · 2015 to 2023
$8.1M
CNS Pain Mechanisms in Early Rheumatoid Arthritis: Implications for the Acute to Chronic Pain TransitionR01AR064850 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEE, YVONNE CLAIRE · 2013 to 2025
$7.9M
Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2019 to 2026
$6.9M
The Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and PainK24AR070892 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2017 to 2026
$1.1M
Mentored Patient-Oriented Research of Novel Mechanisms Linking Pain, Sleep-Wake Patterns, and Autonomic Activity in Rheumatic DiseasesK24AR080840 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Yvonne Claire Lee · 2023 to 2026
$764k
NCATS NIH HHS KL2 TR001424NCATS NIH HHS UL1 TR001422NIAMS NIH HHS K24 AR070892NIAMS NIH HHS K24 AR080840NIAMS NIH HHS P30 AR070254NIAMS NIH HHS P30 AR072571NIAMS NIH HHS P30 AR072579NIAMS NIH HHS R01 AR064850
6 · The paper itself

Abstract

objectiveTo determine if the degree of baseline fibromyalgia (FM) symptoms in patients with rheumatoid arthritis (RA), as indicated by the Fibromyalgia Survey Questionnaire (FSQ) score, predicts RA disease activity after initiation or change of a disease-modifying antirheumatic drug (DMARD).

methodsOne hundred ninety-two participants with active RA were followed for 12 weeks after initiation or change of DMARD therapy. Participants completed the FSQ at the initial visit. The Disease Activity Score in 28 joints using C-reactive protein (DAS28-CRP) was measured at baseline and follow-up to assess RA disease activity. We evaluated the association between baseline FSQ score and follow-up DAS28-CRP. As a secondary analysis, we examined the relationship between the 2 components of the FSQ, the Widespread Pain Index (WPI) and Symptom Severity Scale (SSS), with follow-up DAS28-CRP. Multiple linear regression analyses were performed, adjusting for clinical and demographic variables.

resultsIn multiple linear regression models, FSQ score was independently associated with elevated DAS28-CRP scores 12 weeks after DMARD initiation (B = 0.04,

conclusionHigher levels of FM symptoms weakly predicted worse disease activity after treatment. The primary factor that informed the FSQ's prediction of disease activity was the spatial extent of pain, as measured by the WPI.

Indexed as

Antirheumatic AgentsArthritis, RheumatoidFibromyalgiaC-Reactive ProteinHumansPainSeverity of Illness IndexSurveys and QuestionnairesAntirheumatic AgentsC-Reactive Proteindisease activityfibromyalgiarheumatoid arthritis

Identifiers

PMID36521924
PMCPMC10159881
OpenAlexW4311675042

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.