Evidence map›Paper›PMID 36521683›Full record

ArticleResuscitation2023

Characteristics, therapies, and outcomes of In-Hospital vs Out-of-Hospital cardiac arrest in patients presenting to cardiac intensive care units: From the critical care Cardiology trials network (CCCTN).

Anthony P Carnicelli, Ryan Keane, Kelly M Brown, Daniel B Loriaux, Payton Kendsersky, Carlos L Alviar, Kelly Arps, David D Berg, Erin A Bohula, James A Burke and 21 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Anthony P CarnicelliDivision of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA. Electronic address: carnicel@musc.edu.
Ryan KeaneDivision of Cardiology, Department of Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA.
Kelly M BrownDuke University Hospital, Division of Cardiology, Durham, NC, USA.
Daniel B LoriauxDuke University Hospital, Division of Cardiology, Durham, NC, USA.
Payton KendserskyDivision of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Carlos L AlviarLeon H Charney Division of Cardiology, Bellevue Hospital Center, New York University School of Medicine, New York, NY, USA.
Kelly ArpsDuke University Hospital, Division of Cardiology, Durham, NC, USA.
David D BergTIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Erin A BohulaTIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
James A BurkeLehigh Valley Heart Institute, Allentown, PA, USA.
Jeffrey A DixsonDuke University Hospital, Division of Cardiology, Durham, NC, USA.
Daniel A GerberDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Michael GoldfarbDivision of Cardiology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Christopher B GrangerDuke University Hospital, Division of Cardiology, Durham, NC, USA.
Jianping GuoTIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Robert W HarrisonDuke University Hospital, Division of Cardiology, Durham, NC, USA.
Michael KontosDivision of Cardiology, Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Patrick R LawlerPeter Munk Cardiac Centre, Toronto General Hospital, Toronto, Ontario, Canada.
P Elliott MillerSection of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, USA.
Jose Nativi-NicolauDivision of Cardiology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
L Kristin NewbyDuke University Hospital, Division of Cardiology, Durham, NC, USA.
Lekha RacharlaLehigh Valley Heart Institute, Allentown, PA, USA.
Robert O RoswellLennox Hill Hospital, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Kevin S ShahDivision of Cardiology, Department of Medicine, University of Utah, Salt Lake City, UT, USA.
Shashank S SinhaInova Heart and Vascular Institute, Inova Fairfax Medical Campus, Falls Church, VA, USA.
Michael A SolomonCritical Care Medicine Department, National Institutes of Health Clinical Center and Cardiovascular Branch, National Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda, MD, USA.
Jeffrey TeutebergDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Graham WongDivision of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Sean van DiepenDepartment of Critical Care Medicine and Division of Cardiology, Department of Medicine, University of Alberta, Alberta, Canada.
Jason N KatzDuke University Hospital, Division of Cardiology, Durham, NC, USA.
David A MorrowTIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Postdoctoral Training in Cardiovascular Clinical ResearchT32HL069749 · NHLBI · DUKE UNIVERSITY · PI MARK, DANIEL B · 2003 to 2023
$6.7M
An Observational Study of Cardiac Critical Care Management in Multidisciplinary and Cardiac Intensive Care UnitsZIACL009027 · CLC · CLINICAL CENTER · PI SOLOMON, MICHAEL · 2018 to 2025
$0k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS T32 HL069749
6 · The paper itself

Abstract

backgroundCardiac arrest (CA) is a common reason for admission to the cardiac intensive care unit (CICU), though the relative burden of morbidity, mortality, and resource use between admissions with in-hospital (IH) and out-of-hospital (OH) CA is unknown. We compared characteristics, care patterns, and outcomes of admissions to contemporary CICUs after IHCA or OHCA.

methodsThe Critical Care Cardiology Trials Network is a multicenter network of tertiary CICUs in the US and Canada. Participating centers contributed data from consecutive admissions during 2-month annual snapshots from 2017 to 2021. We analyzed characteristics and outcomes of admissions by IHCA vs OHCA.

resultsWe analyzed 2,075 admissions across 29 centers (50.3% IHCA, 49.7% OHCA). Admissions with IHCA were older (median 66 vs 62 years), more commonly had coronary disease (38.3% vs 29.7%), atrial fibrillation (26.7% vs 15.6%), and heart failure (36.3% vs 22.1%), and were less commonly comatose on CICU arrival (34.2% vs 71.7%), p < 0.001 for all. IHCA admissions had lower lactate (median 4.3 vs 5.9) but greater utilization of invasive hemodynamics (34.3% vs 23.6%), mechanical circulatory support (28.4% vs 16.8%), and renal replacement therapy (15.5% vs 9.4%); p < 0.001 for all. Comatose IHCA patients underwent targeted temperature management less frequently than OHCA patients (63.3% vs 84.9%, p < 0.001). IHCA admissions had lower unadjusted CICU (30.8% vs 39.0%, p < 0.001) and in-hospital mortality (36.1% vs 44.1%, p < 0.001).

conclusionDespite a greater burden of comorbidities, CICU admissions after IHCA have lower lactate, greater invasive therapy utilization, and lower crude mortality than admissions after OHCA.

Indexed as

CardiologyCardiopulmonary ResuscitationOut-of-Hospital Cardiac ArrestComaCritical CareHospitalsHumansIntensive Care UnitsRetrospective StudiesCardiac arrestcardiac critical carecardiac intensive care unitCICUIHCAin-hospital cardiac arrestOHCAout-of-hospital cardiac arresttargeted temperature managementTTM

Identifiers

PMID36521683
PMCPMC9899313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.