ArticlePediatric neurology2023
Deep Venous Remodeling in Unilateral Sturge-Weber Syndrome: Robust Hemispheric Differences and Clinical Correlates.
Article in Pediatric neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Cognitive impairment patterns and associated clinical and imaging characteristics in young patients with Sturge-Weber syndrome.Brain & development · 2026Article
- Introduction of a Brain MRI Scoring System with Clinical Relevance for Sturge-Weber Syndrome.Academic radiology · 2026Article
- Clinical Validation of a Fast MRI Method to Evaluate Brain Vascular and Parenchymal Abnormalities in Sturge-Weber Syndrome.Journal of magnetic resonance imaging : JMRI · 2026Observational
- Beyond the leptomeningeal angioma: a comprehensive review of MR imaging features of Sturge-Weber Syndrome, from early vascular responses to tissue necrosis.Pediatric radiology · 2025Review
- Absence of Deep and Basal Veins Is Common and Clinically Relevant in Sturge-Weber Syndrome.Pediatric neurology · 2025Article
- Biomarker development in Sturge-Weber syndrome.Journal of neurodevelopmental disorders · 2025Review
- SWI brush sign of cerebral parenchymal veins in central nervous system diseases.Japanese journal of radiology · 2025Review
- Feasibility and Potential Diagnostic Value of Noncontrast Brain MRI in Nonsedated Children With Sturge-Weber Syndrome and Healthy Siblings.Journal of child neurology · 2024Article
- Quantification of enlarged deep medullary vein volumes in Sturge-Weber syndrome.Quantitative imaging in medicine and surgery · 2024Article
- Sturge-Weber syndrome: Updates in pathogenesis, diagnosis, and treatment.Annals of the Child Neurology Society · 2023Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundEnlarged deep medullary veins (EDMVs) in patients with Sturge-Weber syndrome (SWS) may provide compensatory venous drainage for brain regions affected by the leptomeningeal venous malformation (LVM). We evaluated the prevalence, extent, hemispheric differences, and clinical correlates of EDMVs in SWS.
methodsFifty children (median age: 4.5 years) with unilateral SWS underwent brain magnetic resonance imaging prospectively including susceptibility-weighted imaging (SWI); children aged 2.5 years or older also had a formal neurocognitive evaluation. The extent of EDMVs was assessed on SWI by using an EDMV hemispheric score, which was compared between patients with right and left SWS and correlated with clinical variables.
resultsEDMVs were present in 89% (24 of 27) of right and 78% (18 of 23) of left SWS brains. Extensive EDMVs (score >6) were more frequent in right (33%) than in left SWS (9%; P = 0.046) and commonly occurred in young children with right SWS. Patients with EDMV scores >4 had rare (less than monthly) seizures, whereas 35% (11 of 31) of patients with EDMV scores ≤4 had monthly or more frequent seizures (P = 0.003). In patients with right SWS and at least two LVM-affected lobes, higher EDMV scores were associated with higher intelligence quotient (P < 0.05).
conclusionsEnlarged deep medullary veins are common in unilateral SWS, but extensive EDMVs appear to develop more commonly and earlier in right hemispheric SWS. Deep venous remodeling may be a compensatory mechanism contributing to better clinical outcomes in some patients with SWS.
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