Evidence map›Paper›PMID 36521049›Full record

ReviewPhysiological reviews2023

The enteric nervous system.

Keith A Sharkey, Gary M Mawe

Open access · greenAbstract readReview
In one paragraph

Review in Physiological reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 230 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
230citing papers in PubMed, 3 pooled it
41.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

230 citing papers in PubMed, 3 syntheses or guidelines pooled it, 293 citations in OpenAlex.

  1. Pooled it
  2. Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?Comprehensive reviews in food science and food safety · 2026
    Pooled it
  3. Pooled it
  4. Review
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  7. The microbiota-proteostasis axis: implications in neurodegenerative diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  8. Article
  9. Review
  10. Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
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  13. Article
  14. Article
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170 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Keith A SharkeyHotchkiss Brain Institute and Snyder Institute for Chronic Diseases, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0001-9560-1711
Gary M MaweDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont.ORCID 0000-0001-8876-8468
University of Calgary · CAUniversity of Vermont · US

Funding

Autoimmune mechanisms of gastrointestinal dysmotility in multiple sclerosisR01DK113800 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MAWE, GARY M · 2017 to 2020
$1.8M
Use of tryptophan-synthesizing bacteria to enhance intestinal motilityR21AT011203 · NCCIH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LAVOIE, BRIGITTE · 2021 to 2022
$421k
NCCIH NIH HHS R21 AT011203NIDDK NIH HHS R01 DK113800
6 · The paper itself

Abstract

Of all the organ systems in the body, the gastrointestinal tract is the most complicated in terms of the numbers of structures involved, each with different functions, and the numbers and types of signaling molecules utilized. The digestion of food and absorption of nutrients, electrolytes, and water occurs in a hostile luminal environment that contains a large and diverse microbiota. At the core of regulatory control of the digestive and defensive functions of the gastrointestinal tract is the enteric nervous system (ENS), a complex system of neurons and glia in the gut wall. In this review, we discuss

Indexed as

Enteric Nervous SystemGastrointestinal TractHumansNeurogliaNeuronsSignal Transductionenteric gliaenteric nervous systeminterstitial cells of Cajalmyenteric plexusvagus nerve

Identifiers

PMID36521049
PMCPMC9970663
OpenAlexW4311806035

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.