ArticlePLoS biology2022
Integrated neural dynamics of sensorimotor decisions and actions.
Article in PLoS biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Article
- Understanding the Cognitive Load of Cell Phone Use While Walking: Distinct Effects of Texting and Phone Conversation.Brain sciences · 2026Article
- Neural activation patterns underlying football decision-making: evidence for the neural proficiency hypothesis.Brain imaging and behavior · 2026Article
- Dynamic geometry remapping of neural activity within frontal and subcortical areas during decision-making.bioRxiv : the preprint server for biology · 2026Article
- Benchmarking criteria to determine latent linear dimensionality in neural data.Scientific reports · 2026Article
- Exploiting prior knowledge in continuous decision-making under uncertainty: the case of tennis experts.Experimental brain research · 2026Article
- A Movement-Independent Signature of Urgency during Human Perceptual Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Alpha and Beta Corticomotor Phase Dynamics Shape Visuomotor Control on a Single-Trial Basis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- No Central Executive? Decision Formation Through Multi-Area Population Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Task-Parametrized Dynamics: Representation of Time and Decisions in Recurrent Neural Networks.bioRxiv : the preprint server for biology · 2025Article
- Joint models reveal human subcortical underpinnings of choice and learning behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Fronto-motor circuits linked to effort-based decision-making and apathy in healthy subjects.Communications biology · 2025Article
- Approach-avoidance conflict recruits lateral frontoparietal and cinguloinsular networks in a predator-prey game setting.Cognitive, affective & behavioral neuroscience · 2025Article
- Two premotor areas (6aα and 6aγ) involved in motor preparation and execution during visually guided locomotion in the cat.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Embodied decisions as active inference.PLoS computational biology · 2025Article
- Visual target and task-critical feedback uncertainty impair different stages of reach planning in motor cortex.Nature communications · 2025Article
- Article
- Beyond Mechanism-Extending Our Concepts of Causation in Neuroscience.The European journal of neuroscience · 2025Review
- Sensorimotor environment but not task rule reconfigures population dynamics in rhesus monkey posterior parietal cortex.Nature communications · 2025Article
- The relationship between confidence and gaze-at-nothing oculomotor dynamics during decision-making.PloS one · 2025Article
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4 authors.
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Abstract
Recent theoretical models suggest that deciding about actions and executing them are not implemented by completely distinct neural mechanisms but are instead two modes of an integrated dynamical system. Here, we investigate this proposal by examining how neural activity unfolds during a dynamic decision-making task within the high-dimensional space defined by the activity of cells in monkey dorsal premotor (PMd), primary motor (M1), and dorsolateral prefrontal cortex (dlPFC) as well as the external and internal segments of the globus pallidus (GPe, GPi). Dimensionality reduction shows that the four strongest components of neural activity are functionally interpretable, reflecting a state transition between deliberation and commitment, the transformation of sensory evidence into a choice, and the baseline and slope of the rising urgency to decide. Analysis of the contribution of each population to these components shows meaningful differences between regions but no distinct clusters within each region, consistent with an integrated dynamical system. During deliberation, cortical activity unfolds on a two-dimensional "decision manifold" defined by sensory evidence and urgency and falls off this manifold at the moment of commitment into a choice-dependent trajectory leading to movement initiation. The structure of the manifold varies between regions: In PMd, it is curved; in M1, it is nearly perfectly flat; and in dlPFC, it is almost entirely confined to the sensory evidence dimension. In contrast, pallidal activity during deliberation is primarily defined by urgency. We suggest that these findings reveal the distinct functional contributions of different brain regions to an integrated dynamical system governing action selection and execution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.