ArticleInfectious diseases and therapy2023
Association Between Lactate and 28-Day Mortality in Elderly Patients with Sepsis: Results from MIMIC-IV Database.
Article in Infectious diseases and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prediction models for mortality in patients with sepsis: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Risk analysis of the association between lactate-to-hematocrit ratio and poor prognosis in critical patients with cirrhosis.Medicine · 2026Article
- Serum iron is associated with the prognosis in sepsis based on a large-scale database.BMC infectious diseases · 2026Article
- Association Between Lactate and ICU-Acquired Infection in Critically Ill Patients With Sepsis: A Retrospective Study Using the MIMIC-IV Database.Journal of cellular and molecular medicine · 2026Article
- Evaluation of the clinical characteristics and risk factors for in-hospital mortality amongst older persons admitted with bacteraemia in a geriatric ward - a single tertiary centre review.BMC geriatrics · 2026Article
- Prognostic Value of the Albumin-to-Prealbumin Ratio in Elderly Patients with Sepsis.Journal of clinical medicine · 2026Article
- Article
- Lactate and lactylation in sepsis: regulation of immune-metabolic crosstalk and organ injury.Frontiers in immunology · 2026Review
- Admission lactate and short-term mortality in the geriatric ICU: comparison with established severity scores.Aging clinical and experimental research · 2025Article
- Prognostic role of creatine kinase-MB in elderly patients with sepsis.European journal of medical research · 2025Article
- Associations of lactate-to-hematocrit ratio with short- and long-term prognoses in critically ill patients with cirrhosis and sepsis: a retrospective cohort study.BMC infectious diseases · 2025Article
- Early Prediction of In-Hospital Mortality in Patients with Acute Infections: Development of the Acute Severity Infection Score (ASIs).Infectious diseases and therapy · 2025Article
- Non-linear relationship between serum iron levels and 28-day mortality in sepsis patients: a retrospective study.Scientific reports · 2025Observational
- Article
- Optical Bionanosensors for Sepsis Diagnostics.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Developing a rapid screening tool for high-risk ICU patients of sepsis: integrating electronic medical records with machine learning methods for mortality prediction in hospitalized patients-model establishment, internal and external validation, and visualization.Journal of translational medicine · 2025Article
- Characteristics and prognosis of patients with pathogenic microorganism-positive sepsis AKI from ICU: a retrospective cohort study.Frontiers in cellular and infection microbiology · 2025Article
- Phase-specific mortality risk of serum lactate thresholds in very low birth weight infants with late-onset sepsis: a retrospective cohort study.Frontiers in medicine · 2025Article
- Lactate dehydrogenase is an indicator for outcomes of short-term and long-term in septic patients.PloS one · 2025Article
- Non-linear association between lactate and 28 days mortality in elderly patients with sepsis across different SOFA score groups: results from the eICU Collaborative Research Database.Frontiers in medicine · 2025Article
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5 authors.
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Abstract
introductionThis study aimed to explore the association of serum lactate with clinical outcomes in elderly patients with sepsis based on data from the MIMIC-IV database.
methodsAll elderly patients with sepsis (age ≥ 65 years) were included. Different models were constructed for exploring the relationships between lactate and 28-day mortality. A two-segment linear regression model was performed to verify the threshold effects of lactate on clinical outcomes and smooth curve fitting was performed.
resultsA total of 4199 elderly patients with sepsis were included. The 28-day mortality was 32.22% (n = 1395). After adjustment for all potential cofounders, for each 1 mmol/l increment in lactate, the odds ratio (OR) of 28-day mortality was 1.23 (95% CI 1.18-1.28, P < 0.0001). Smooth fitting curves indicated a non-linear positive relationship between lactate and 28-day mortality. The turning point of lactate level was 5.7 mmol/l: at ≤ 5.7 mmol/l, with each 1 mmol/l increment in lactate, the risk of 28-day mortality increased significantly (OR 1.32, 95% CI 1.25-1.38, P < 0.0001); the significantly positive relationship was still present at lactate > 5.7 mmol/l (OR 1.10, 95% CI 1.04-1.18, P = 0.0019). The area under the ROC curve (AUC) of lactate was 0.618 (95% CI 0.599-0.635) and the cutoff value of lactate was 2.4 mmol/l with a sensitivity of 0.483 and a specificity of 0.687.
conclusionIn elderly patients with sepsis, a non-linear positive relationship was discovered between serum lactate and 28-day mortality. Physicians should be alert to lactate assessment at admission and pay more attention to those patients with higher levels of lactate.
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