Evidence map›Paper›PMID 36520251›Full record

Trial reportArchives of women's mental health2023

A 1-week sleep and light intervention improves mood in premenstrual dysphoric disorder in association with shifting melatonin offset time earlier.

Barbara L Parry, Charles J Meliska, L Fernando Martinez, Ana M Lopez, Diane L Sorenson, Sharron E Dawes, Jeffrey A Elliott, Richard L Hauger

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of women's mental health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01799733 (Alternative Treatments for Premenstrual Dysphoric Disorder), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01799733 nacompletednot on this map

Alternative Treatments for Premenstrual Dysphoric Disorder

TypeinterventionalSponsorUniversity of California, San DiegoRan2013 to 2018Enrolled43ConditionsPremenstrual Dysphoric DisorderArmsLWT+AM BWL, EWT+PM BWL
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Barbara L ParryDepartment of Psychiatry, University of California, 9500 Gilman Dr., La Jolla, La Jolla, CA, 92093-0804, USA. bparry@ucsd.edu.
Charles J MeliskaCenter for Circadian Biology, San Diego, CA, USA.
L Fernando MartinezDepartment of Psychiatry, University of California, 9500 Gilman Dr., La Jolla, La Jolla, CA, 92093-0804, USA.
Ana M LopezDepartment of Psychiatry, University of California, 9500 Gilman Dr., La Jolla, La Jolla, CA, 92093-0804, USA.
Diane L SorensonDepartment of Psychiatry, University of California, 9500 Gilman Dr., La Jolla, La Jolla, CA, 92093-0804, USA.
Sharron E DawesDepartment of Psychiatry, University of California, 9500 Gilman Dr., La Jolla, La Jolla, CA, 92093-0804, USA.
Jeffrey A ElliottCenter for Circadian Biology, San Diego, CA, USA.
Richard L HaugerCenter for Behavior Genetics of Aging, San Diego, CA, USA.
Circadian (United States) · USUniversity of California, San Diego · USVA San Diego Healthcare System · US

Funding

Alternative Treatments for Premenstrual Dysphoric DisorderR01AT007169 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PARRY, BARBARA L · 2013 to 2017
$1.8M
Foundation for the National Institutes of Health R01AT007169NCCIH NIH HHS R01 AT007169
6 · The paper itself

Abstract

To test the hypothesis that 1 week of combined sleep and light interventions (SALI), which phase-advance (shift earlier) melatonin circadian rhythms, improves mood significantly more than phase-delay (shift later) SALI. After a 2-month diagnostic evaluation for premenstrual dysphoric disorder (PMDD per DSM-5 criteria) in a university clinical research setting, 44 participants enrolled in baseline studies were randomized in the luteal phase at home to (A) a phase-advance intervention (PAI): 1 night of late-night wake therapy (LWT: sleep 9 pm-1 am) followed by 7 days of the morning (AM) bright white light (BWL), or (B) a phase-delay intervention (PDI): 1 night of early-night wake therapy (EWT: sleep 3-7 am) plus 7 days of the evening (PM) BWL. After a month of no intervention, participants underwent the alternate intervention. Outcome measures were mood, the melatonin metabolite, 6-sulfatoxymelatonin (6-SMT), and actigraphy (to assess protocol compliance). At baseline, atypical depression correlated positively with phase delay in 6-SMT offset time (r = .456, p = .038). PAI advanced 6-SMT offset from baseline more than PDI (p < .05), and improved raw mood scores more than PDI (p < .05). As hypothesized, percent improvement in mood correlated positively with a phase advance from baseline in 6-SMT offset time (p < .001). Treatment with 1 night of advanced/restricted sleep followed by 7 days of AM BWL (PAI) was more efficacious in reducing PMDD depression symptoms than a PDI; mood improvement occurred in association with phase advance in 6-SMT offset time. Combined SALIs offer safe, efficacious, rapid-acting, well-tolerated, non-pharmacological, non-hormonal, affordable, repeatable home interventions for PMDD. Clinical Trials.gov NCT # NCT01799733.

Indexed as

MelatoninPremenstrual Dysphoric DisorderPremenstrual SyndromeCircadian RhythmFemaleHumansLuteal PhaseSleepMelatoninLight treatmentMelatonin circadian rhythmsPremenstrual dysphoric disorderSleepWake therapy

Identifiers

PMID36520251
PMCPMC9908689
OpenAlexW4311581086

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.