Evidence map›Paper›PMID 36520196›Full record

ArticleVirchows Archiv : an international journal of pathology2023

Rare adult pilocytic astrocytoma of the septum pellucidum with novel RIN2::BRAF fusion.

Xinglei Liu, Xiaoxiao Dai, Chungang Dai, Qin Zhu, Ailin Chen, Yanming Chen, Nan Chen, Ping Chen, Rong Rong, Changjun Shi and 2 more

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Cancer biology & therapy · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Xinglei Liu *Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Xiaoxiao Dai *Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Chungang Dai *Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Qin ZhuDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Ailin ChenDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Yanming ChenDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Nan ChenSuzhou Sano Precision Medicine Ltd, Suzhou, China.
Ping ChenSuzhou Sano Precision Medicine Ltd, Suzhou, China.
Rong RongSuzhou Sano Precision Medicine Ltd, Suzhou, China.
Changjun ShiSuzhou Sano Precision Medicine Ltd, Suzhou, China.
Sheng XiaoDepartment of Pathology, Brigham and Women's Hospital, Boston, USA.
Jun DongDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. dongjun@suda.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pilocytic astrocytoma is mostly a pediatric tumor with the majority of patients under age 20. Although tumors can occur throughout neuraxis, most tumors are in the cerebellum and optic chiasm. Pilocytic astrocytoma in unusual locations is often associated with different genetic alterations than the classic KIAA1549::BRAF fusion. We report a rare adult pilocytic astrocytoma of the septum pellucidum that presented with progressive headache. A detailed genomic evaluation found a fusion between BRAF and a novel partner RIN2, a gene overexpressed in both low-grade glioma and glioblastoma. The RIN2::BRAF transcript encodes a chimeric protein containing a dimerization domain SH2 and an intact kinase domain, consistent with a prototypic oncogenic kinase rearrangement. In addition, we discuss the potential oncogenic mechanisms of BRAF signaling and its implication in targeted therapy with kinase inhibitors.

Indexed as

AstrocytomaBrain NeoplasmsGliomaAdolescentCarrier ProteinsChildGuanine Nucleotide Exchange FactorsHumansProto-Oncogene Proteins B-rafSeptum PellucidumSignal TransductionYoung AdultBRAF protein, humanCarrier ProteinsGuanine Nucleotide Exchange FactorsProto-Oncogene Proteins B-rafRIN2 protein, humanAdult pilocytic astrocytomaPellucid septumRIN2::BRAF fusion

Identifiers

PMID36520196

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.