Evidence map›Paper›PMID 36520190›Full record

ArticleEuropean journal of nutrition2023

Protective effects of Bifidobacterium bifidum FL-228.1 on dextran sulfate sodium-induced intestinal damage in mice.

Rui Wang, Malina Kuerman, Qingyu Cui, Xiaoying Tian, Yu Zhou, Huaxi Yi, Pimin Gong, Kai Lin, Zhe Zhang, Tongjie Liu and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Probiotics and the intestinal tight junction barrier function.Frontiers in cell and developmental biology · 2025
    Review
  7. Microorganisms · 2024
    Article
  8. Frontiers in microbiology · 2024
    Article
  9. Role ofCurrent developments in nutrition · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Rui WangCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao, 266003, China.
Malina KuermanCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao, 266003, China.
Qingyu CuiCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao, 266003, China.
Xiaoying TianCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao, 266003, China.
Yu ZhouCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao, 266003, China.
Huaxi YiCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao, 266003, China.
Pimin GongCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao, 266003, China.
Kai LinCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao, 266003, China.
Zhe ZhangCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao, 266003, China.
Tongjie LiuCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao, 266003, China. liutongjie@ouc.edu.cn.
Lanwei ZhangCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao, 266003, China. zhanglanwei@ouc.edu.cn.ORCID http://orcid.org/0000-0003-3459-2975
Ocean University of China · CN

Funding

National Natural Science Foundation of China 31901664the Project of Taishan Industry Leading Talent of Shandong Province LJNY202101
6 · The paper itself

Abstract

purposeNumerous studies have found that probiotics benefit the intestinal barrier. However, the prophylactic effects of probiotics on the intestinal barrier, i.e., if probiotics exert protective effects in healthy individuals to defend them against harmful elements, have seldomly been reported. The present study aimed to investigate the possible mechanisms of potential strains with the function of preventing intestinal barrier damage.

methodsThis study investigated nine potential probiotic strains using in vitro and in vivo models on their intestinal barrier-protecting properties. Transcriptomic was then employed to decipher the underlying mechanisms of action of the strains.

resultsThe results showed that the strains, to varying degrees, regulated the ratio of interleukin (IL)-10 and IL-12 in peripheral blood mononuclear cells (PBMCs), increased the transepithelial electrical resistance (TEER) values, and decreased Caco-2 cell monolayers permeability. Correspondingly, the strains showed different prophylactic efficacies in protecting mice from dextran sulfate sodium (DSS)-induced intestinal barrier damage. Remarkably, Bifidobacterium bifidum FL-228.1 (FL-228.1) showed the best prophylactic efficacies in protecting mice from DSS-induced intestinal barrier damage. Further research suggested that FL-228.1 exerted its prophylactic effects by enhancing mucin 2 (Muc2) production and Claudin (Cldn)-4 in the colon. Furthermore, the transcriptomic and protein-protein interactions (PPI) analyses indicated that the inhibition of NLRP3 and the activation of PPARγ and TLR2 could be involved in protecting the intestinal barrier by FL-228.1.

conclusionBifidobacterium bifidum FL-228.1 may be developed as a promising probiotic for the prevention of intestinal barrier damage via PPARγ/NLRP3/ TLR2 pathways by enhancing Muc2 and Cldn-4.

Indexed as

Bifidobacterium bifidumColitisProbioticsAnimalsCaco-2 CellsDextran SulfateDisease Models, AnimalIntestinal MucosaLeukocytes, MononuclearMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinPPAR gammaToll-Like Receptor 2Dextran SulfateNLR Family, Pyrin Domain-Containing 3 ProteinPPAR gammaToll-Like Receptor 2Intestinal barrierMucin2ProbioticsTight junction proteinsTranscriptomics

Identifiers

PMID36520190
OpenAlexW4311576652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.