Evidence map›Paper›PMID 36520034›Full record

ReviewCancer science2023

Recent advances in the molecular understanding of medulloblastoma.

Yusuke Funakoshi, Yuriko Sugihara, Atsuhito Uneda, Takuma Nakashima, Hiromichi Suzuki

Abstract readReview
In one paragraph

Review in Cancer science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yusuke FunakoshiDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Chuo-ku, Japan.ORCID https://orcid.org/0000-0002-3039-2370
Yuriko SugiharaDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Chuo-ku, Japan.
Atsuhito UnedaDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Chuo-ku, Japan.
Takuma NakashimaDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Chuo-ku, Japan.
Hiromichi SuzukiDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Chuo-ku, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medulloblastoma is the most common pediatric malignant brain tumor composed of four molecular subgroups. Recent intensive genomics has greatly contributed to our understanding of medulloblastoma pathogenesis. Sequencing studies identified novel mutations involved in the cyclic AMP-dependent pathway or RNA processing in the Sonic Hedgehog (SHH) subgroup, and core-binding factor subunit alpha (CBFA) complex in the group 4 subgroup. Likewise, single-cell sequencing provided detailed insights into the cell of origin associated with brain development. In this review, we will summarize recent findings by sequencing analyses for medulloblastoma.

Indexed as

Brain NeoplasmsCerebellar NeoplasmsMedulloblastomaBrainChildHedgehog ProteinsHumansHedgehog ProteinsCBFA complexmedulloblastomarhombic lipRNA processingSHH signaling pathway

Identifiers

PMID36520034
PMCPMC9986075

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.