Evidence map›Paper›PMID 36519944›Full record

ArticleMicrobiology spectrum2023

Antibiotic Tolerance and Treatment Outcomes in Cystic Fibrosis Methicillin-Resistant Staphylococcus aureus Infections.

Kuan-Yi Lu, Nikki J Wagner, Amanda Z Velez, Agathe Ceppe, Brian P Conlon, Marianne S Muhlebach

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. GrowingInfection and immunity · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. CRISPR-driven strategies to disrupt methicillin-resistantFrontiers in cellular and infection microbiology · 2026
    Review
  6. Article
  7. Antimicrobial Activity ofAntibiotics (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Review
  10. Tracking the progeny of bacterial persisters using a CRISPR-based genomic recorder.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kuan-Yi LuDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-3663-377X
Nikki J WagnerDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Amanda Z VelezDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Agathe CeppeMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Brian P ConlonDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-2155-8375
Marianne S MuhlebachMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
University of North Carolina at Chapel Hill · US

Funding

Antibiotic activities against S. aureus during P. aeruginosa co-infectionR01AI137273 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CONLON, BRIAN PATRICK · 2018 to 2022
$2.0M
NIAID NIH HHS R01 AI137273
6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is highly prevalent in U.S. cystic fibrosis (CF) patients and is associated with worse clinical outcomes in CF. These infections often become chronic despite repeated antibiotic therapy. Here, we assessed whether bacterial phenotypes, including antibiotic tolerance, can predict the clinical outcomes of MRSA infections. MRSA isolates (

Indexed as

Cystic FibrosisMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAnti-Bacterial AgentsHemolysisHumansMicrobial Sensitivity TestsTreatment OutcomeVancomycinAnti-Bacterial AgentsVancomycinantibiotic tolerancecystic fibrosisMRSApersistenceStaphylococcus aureustreatment outcome

Identifiers

PMID36519944
PMCPMC9927320
OpenAlexW4311576964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.