Evidence map›Paper›PMID 36519896›Full record

ArticleJournal of virology2023

Heat Shock Protein Family A Member 1 Promotes Intracellular Amplification of Hepatitis B Virus Covalently Closed Circular DNA.

Liudi Tang, Ping An, Qiong Zhao, Cheryl A Winkler, Jinhong Chang, Ju-Tao Guo

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Liudi TangDepartment of Experimental Therapeutics, Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA.
Ping AnBasic Research Laboratory, Molecular Genetic Epidemiology Section, Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Qiong ZhaoDepartment of Experimental Therapeutics, Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA.
Cheryl A WinklerBasic Research Laboratory, Molecular Genetic Epidemiology Section, Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Jinhong ChangDepartment of Experimental Therapeutics, Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA.
Ju-Tao GuoDepartment of Experimental Therapeutics, Baruch S. Blumberg Institute, Doylestown, Pennsylvania, USA.ORCID 0000-0001-5335-2788
Baruch S. Blumberg Institute · USFrederick National Laboratory for Cancer Research · US

Funding

Evaulation of therapeutic benefits of HBV nucleocapsid assembly inhibitorsR01AI113267 · NIAID · DREXEL UNIVERSITY · PI DU, YANMING, GUO, JU-TAO · 2014 to 2018
$2.9M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI113267NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

Hepatitis B virus (HBV) contains a partially double-stranded relaxed circular DNA (rcDNA) genome that is converted into a covalently closed circular DNA (cccDNA) in the nucleus of the infected hepatocyte by cellular DNA repair machinery. cccDNA associates with nucleosomes to form a minichromosome that transcribes RNA to support the expression of viral proteins and reverse transcriptional replication of viral DNA. In addition to the

Indexed as

DNA, CircularHepatitis B virusHSP70 Heat-Shock ProteinsDNA, ViralHepatitis B, ChronicHumansRad51 RecombinaseRNA, Small InterferingVirus ReplicationDNA, CircularDNA, ViralHSP70 Heat-Shock ProteinsHSPA1A protein, humanRAD51 protein, humanRad51 RecombinaseRNA, Small InterferingcccDNAhepatitis B virusHSPA1viral replication

Identifiers

PMID36519896
PMCPMC9888207
OpenAlexW4311582291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.