Evidence map›Paper›PMID 36519835›Full record

ArticleBioinformatics (Oxford, England)2023

The COMER web server for protein analysis by homology.

Justas Dapkūnas, Mindaugas Margelevičius

Open access · hybridAbstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Frontiers in cellular and infection microbiology · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Justas DapkūnasInstitute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius 10257, Lithuania.ORCID 0000-0002-0496-6107
Mindaugas MargelevičiusInstitute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius 10257, Lithuania.ORCID 0000-0003-4981-6708
Vilnius University · LT

Funding

European Regional Development Fund 01.2.2-LMT-K-718-01-0028
6 · The paper itself

Abstract

summarySequence homology is a basic concept in protein evolution, structure and function studies. However, there are not many different tools and services for homology searches being sensitive, accurate and fast at the same time. We present a new web server for protein analysis based on COMER2, a sequence alignment and homology search method that exhibits these characteristics. COMER2 has been upgraded since its last publication to improve its alignment quality and ease of use. We demonstrate how the user can benefit from using it by providing examples of extensive annotation of proteins of unknown function. Among the distinctive features of the web server is the user's ability to submit multiple queries with one click of a button. This and other features allow for transparently running homology searches-in a command-line, programmatic or graphical environment-across multiple databases with multiple queries. They also promote extensive simultaneous protein analysis at the sequence, structure and function levels. AVAILABILITY AND IMPLEMENTATION: The COMER web server is available at https://bioinformatics.lt/comer. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Indexed as

Sequence Analysis, ProteinSoftwareComputersInternetProteinsSequence AlignmentProteins

Identifiers

PMID36519835
PMCPMC9825750
OpenAlexW4311573121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.