Evidence map›Paper›PMID 36519814›Full record

ArticleJournal of the National Cancer Institute. Monographs2022

Infrastructure to Support Accrual of Older Adults to National Cancer Institute Clinical Trials.

Gretchen Kimmick, Mina S Sedrak, Grant Williams, Nadine J McCleary, Ashley E Rosko, Jeffrey L Berenberg, Rachel A Freedman, Mary Lou Smith, Amina Ahmed, Hyman B Muss and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the National Cancer Institute. Monographs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 1 country.

Gretchen KimmickDepartment of Medicine, Division of Medical Oncology, Duke University Medical Center/Duke Cancer Institute, Durham, NC, USA.ORCID 0000-0001-7096-9624
Mina S SedrakDepartment of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA, USA.ORCID 0000-0002-8379-391X
Grant WilliamsInstitute for Cancer Outcomes & Survivorship and Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Nadine J McClearyDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Ashley E RoskoDepartment of Internal Medicine, Division of Hematology, The Ohio State University, Columbus, OH, USA.
Jeffrey L BerenbergDepartment of Medicine, Division of Medical Oncology, Hawaii Minority Underserved National Cancer Institute Community Oncology Research Program, Honolulu, HI, USA.
Rachel A FreedmanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Mary Lou SmithResearch Advocacy Network, Plano, TX, USA.
Amina AhmedDepartment of Obstetrics and Gynecology, Division of Gyn Oncology, Rush University Medical Center, Chicago, IL, USA.
Hyman B MussLineberger Comprehensive Cancer Center, Division of Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Selina ChowDepartment of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL, USA.
William DaleDepartment of Supportive Care Medicine, City of Hope, Duarte, CA, USA.ORCID 0000-0001-8674-9394
City of Hope · USDana-Farber Cancer Institute · USDuke Medical Center · USNational Cancer Institute · USResearch Advocacy Network · USRush University Medical Center · USThe Ohio State University · USUniversity of Alabama at Birmingham · USUniversity of Chicago Medical Center · USUniversity of North Carolina at Chapel Hill · US

Funding

The Hawaii NCORPUG1CA189804 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Jared Acoba, Jeffrey Lee Berenberg · 2014 to 2026
$15.7M
Targeting Senescence to Improve Frailty in Older Cancer SurvivorsK76AG074918 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SEDRAK, MINA S · 2022 to 2024
$729k
Improving Clinical Trial Participation of Older Adults with CancerR03AG064377 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SEDRAK, MINA S · 2019 to 2020
$260k
NCI NIH HHS UG1 CA189804NIA NIH HHS K76 AG074918NIA NIH HHS R03 AG064377
6 · The paper itself

Abstract

As part of ongoing efforts to meaningfully improve recruitment, enrollment, and accrual of older adults into cancer clinical trials, the National Cancer Institute (NCI) sponsored a workshop with experts across the country entitled Engaging Older Adults in the NCI Clinical Trials Network: Challenges and Opportunities. Three working groups, including Study Design, Infrastructure, and Stakeholders, were formed, who worked together to offer synergistic improvements in the system. Here, we summarize the workshop discussions of the Infrastructure Working Group, whose goal was to address infrastructural challenges, identify underlying resources, and offer solutions to facilitate accrual of older adults into cancer clinical trials. Based on preconference work and workshop discussions, four key recommendations to strengthen NCI infrastructure were proposed: 1) further centralize resources and expertise; 2) provide training for clinical research staff; (3) develop common data elements; and 4) evaluate what works and does not work. These recommendations provide a strategy to improve the infrastructure to enroll more older adults in cancer clinical trials.

Indexed as

NeoplasmsAgedClinical Trials as TopicHumansNational Cancer Institute (U.S.)Research DesignUnited States

Identifiers

PMID36519814
PMCPMC9753220
OpenAlexW4311807934

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.