Evidence map›Paper›PMID 36519726›Full record

ArticleACS infectious diseases2023

Cloacaenodin, an Antimicrobial Lasso Peptide with Activity against

Drew V Carson, Monica Patiño, Hader E Elashal, Alexis Jaramillo Cartagena, Yi Zhang, Megan E Whitley, Larry So, Angelo K Kayser-Browne, Ashlee M Earl, Roby P Bhattacharyya and 1 more

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. HFGuidedDesign:Chemical science · 2026
    Article
  3. Tangled Tail of Mechanically Interlocked Peptides.Journal of the American Chemical Society · 2026
    Review
  4. Repositioning the Leader Peptide in Graspetide Biosynthesis.Journal of the American Chemical Society · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Mutexa: A Computational Ecosystem for Intelligent Protein Engineering.Journal of chemical theory and computation · 2023
    Review
  11. Article
  12. Bacterial natural product discovery by heterologous expression.Journal of industrial microbiology & biotechnology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Drew V CarsonDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0002-4209-2199
Monica PatiñoDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States.
Hader E ElashalDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States.
Alexis Jaramillo CartagenaInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Yi ZhangDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States.
Megan E WhitleyDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States.
Larry SoDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0001-8863-7601
Angelo K Kayser-BrowneDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.
Ashlee M EarlInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Roby P BhattacharyyaInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.ORCID 0000-0001-6955-5088
A James LinkDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0001-5066-9691
Princeton University · USBroad Institute · US

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI EARL, ASHLEE MIRIAM · 2014 to 2024
$66.5M
Lasso Peptide DiscoveryR01GM107036 · NIGMS · PRINCETON UNIVERSITY · PI LINK, AARON JAMES · 2014 to 2022
$2.9M
NIAID NIH HHS U19 AI110818NIGMS NIH HHS R01 GM107036
6 · The paper itself

Abstract

Using genome mining and heterologous expression, we report the discovery and production of a new antimicrobial lasso peptide from species related to the

Indexed as

Anti-Bacterial AgentsEnterobacterAntimicrobial PeptidesCarbapenemsPeptidesAnti-Bacterial AgentsAntimicrobial PeptidesCarbapenemsPeptidesantimicrobial lasso peptidecarbapenem-resistant EnterobacteralescloacaenodinEnterobacter cloacaegenome miningRiPPs

Identifiers

PMID36519726
PMCPMC10038104
OpenAlexW4311587850

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.