ArticleeLife2022
Automated hippocampal unfolding for morphometry and subfield segmentation with HippUnfold.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed.
- Advancing the Volumetric Analysis of Ultra-Low-Field Brain MRI Using Image-to-Image Translation.Magnetic resonance in medicine · 2026Article
- Functional Imaging of Hippocampal Layers Using VASO and BOLD on the Next Generation (NexGen) 7T Scanner.Human brain mapping · 2026Article
- Impaired autobiographical remembering and future thinking in temporal lobe epilepsy.Epilepsy & behavior : E&B · 2026Article
- Association Between Anterior Hippocampal Gyrification and Episodic Memory Performance in Neurotypical Young Adults.Hippocampus · 2026Article
- Physical Activity Is Associated With Age-Related Differences in Hippocampal Macrostructure and Microstructure in Middle-Aged and Older Adults.Hippocampus · 2026Article
- High-Resolution Diffusion Kurtosis Imaging of Hippocampus Subfields Across the Healthy Lifespan.NMR in biomedicine · 2026Article
- Distinct spatial associations of adversity with hippocampal macro- and microstructure in early adolescence.bioRxiv : the preprint server for biology · 2026Article
- Selective convergence and graded divergence of hippocampal and amygdala subregions using functional connectivity.bioRxiv : the preprint server for biology · 2026Article
- The hippocampus becomes topographically and functionally specialized along the longitudinal axis with development.Nature communications · 2026Article
- MRecover: A Conditional Generative Model for Recovering Motion- Corrupted MR images Using AI Generated Contrast.Research square · 2026Article
- Co-simulation framework combining a microscopically detailed point neuron model of the hippocampal CA1 region with the macroscopic high-resolution virtual brain model.Journal of computational neuroscience · 2026Article
- Lamellar Normative Modelling of the Hippocampus Across the Human Lifespan.bioRxiv : the preprint server for biology · 2026Article
- Longitudinal evaluation of hippocampal subfields volumes and episodic memory in breast cancer patients and healthy controls.Brain imaging and behavior · 2026Article
- Duration-dependent hippocampal structural changes in focal epilepsy: multicenter neuroimaging evidence.Journal of translational medicine · 2026Article
- Spatial and semantic memory reorganize a hippocampal long-axis gradient.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Multi-dimensional diffusion MRI at ultra-high gradient strength for mapping axonal architecture and microstructure in the primate brain.bioRxiv : the preprint server for biology · 2026Article
- Microstructural variation of hippocampal substructures across childhood and adolescence quantified with high-gradient diffusion MRI.Communications biology · 2026Article
- Hippocampal morphometry is altered in infants with congenital heart disease.Brain communications · 2026Article
- Complementary roles of the human perirhinal and the entorhinal cortex in the hippocampal retrieval of episodic memory.iScience · 2025Article
- Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Like neocortical structures, the archicortical hippocampus differs in its folding patterns across individuals. Here, we present an automated and robust BIDS-App, HippUnfold, for defining and indexing individual-specific hippocampal folding in MRI, analogous to popular tools used in neocortical reconstruction. Such tailoring is critical for inter-individual alignment, with topology serving as the basis for homology. This topological framework enables qualitatively new analyses of morphological and laminar structure in the hippocampus or its subfields. It is critical for refining current neuroimaging analyses at a meso- as well as micro-scale. HippUnfold uses state-of-the-art deep learning combined with previously developed topological constraints to generate uniquely folded surfaces to fit a given subject's hippocampal conformation. It is designed to work with commonly employed sub-millimetric MRI acquisitions, with possible extension to microscopic resolution. In this paper, we describe the power of HippUnfold in feature extraction, and highlight its unique value compared to several extant hippocampal subfield analysis methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.