Evidence map›Paper›PMID 36519470›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2023

A New Autosomal

Rebecca A Deaton, Gamze Bulut, Vlad Serbulea, Anita Salamon, Laura S Shankman, Anh Tram Nguyen, Gary K Owens

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. PERK Is Dispensable for Smooth Muscle Cell Phenotype Switching in Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
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  7. Review
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  9. Review
  10. Article
  11. Article
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  15. Article
  16. Article
  17. Hypercholesterolemia-induced LXR signaling in smooth muscle cells contributes to vascular lesion remodeling and visceral function.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rebecca A DeatonRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville (R.A.D., V.S., A.S., L.S.S., G.K.O.).ORCID 0000-0001-7569-1924
Gamze BulutDepartment of Biology' College of William and Mary, Williamsburg, VA (G.B.).ORCID 0000-0002-8344-3338
Vlad SerbuleaRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville (R.A.D., V.S., A.S., L.S.S., G.K.O.).ORCID 0000-0002-9988-4410
Anita SalamonRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville (R.A.D., V.S., A.S., L.S.S., G.K.O.).ORCID 0000-0002-5708-9494
Laura S ShankmanRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville (R.A.D., V.S., A.S., L.S.S., G.K.O.).ORCID 0000-0003-4983-9467
Anh Tram NguyenDivision of Cardiology' Duke University School of Medicine, Durham, NC (A.T.N.).ORCID 0000-0001-8656-4816
Gary K OwensRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville (R.A.D., V.S., A.S., L.S.S., G.K.O.).ORCID 0000-0002-7119-9657
University of Virginia · USDuke University · USWilliam & Mary · US

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
Endothelial Cell to Mesenchymal Cell Transitions Play a Critical Biological Sex- and Aging-Dependent Role in Formation and Maintenance of the Acta2+ Atherosclerotic Lesion Protective Fibrous CapR01HL156849 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2022 to 2025
$3.2M
IL1beta signaling in SMCpromotes beneficial changes in late stage atherosclerotic lesion pathogenesisR01HL141425 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2019 to 2022
$3.1M
Defining SMC phenotypes critical in late stage atherosclerosis pathogenesisR01HL136314 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2018 to 2021
$3.0M
Role of Metabolic Reprogramming in Formation and Maintenance of the Acta2+ Atherosclerotic Lesion Protective Fibrous CapR01HL155165 · NHLBI · UNIVERSITY OF VIRGINIA · PI OWENS, GARY K · 2021 to 2024
$2.9M
NHLBI NIH HHS R01 HL136314NHLBI NIH HHS R01 HL141425NHLBI NIH HHS R01 HL155165NHLBI NIH HHS R01 HL156849NHLBI NIH HHS T32 HL007284
6 · The paper itself

Abstract

backgroundThe

methodsA

results

conclusionsWe generated and validated the function of an autosomal

Indexed as

IntegrasesMyocytes, Smooth MuscleAnimalsCell LineageFemaleGene Knockout TechniquesMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicTamoxifenIntegrasesTamoxifenarteriesfemalemice, transgenicmyocytes, smooth musclemyosin heavy chainstamoxifen

Identifiers

PMID36519470
PMCPMC9877184
OpenAlexW4311586211

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.