Evidence map›Paper›PMID 36519087›Full record

ArticleFood chemistry: X2022

Exogenous γ-aminobutyric acid strengthens phenylpropanoid and nitrogen metabolism to enhance the contents of flavonoids, amino acids, and the derivatives in edamame.

Gaobo Yu, Fengqiong Chen, Yating Wang, Qiusen Chen, Hanlin Liu, Jin Tian, Mengxue Wang, Chunyuan Ren, Qiang Zhao, Fengjun Yang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food chemistry: X, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Exogenous GABA mitigates flower senescence inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2025
    Article
  4. Article
  5. Horticulture research · 2024
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Gaobo YuHeilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.
Fengqiong ChenHeilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.
Yating WangHeilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.
Qiusen ChenHeilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.
Hanlin LiuHeilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.
Jin TianHeilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.
Mengxue WangHeilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.
Chunyuan RenHeilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.
Qiang ZhaoHeilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.
Fengjun YangHeilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.
Yunyan ShengHeilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.
Jinpeng WeiHeilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.
Yuxian ZhangHeilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, China.
Heilongjiang Bayi Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γ-aminobutyric acid (GABA) has been reported to improve stress resistance in plants. Nonetheless, little is known about the effects of GABA on the nutritional quality and regulatory mechanisms of edamame. Therefore, we analyzed the flavonoid and amino acid (AA) metabolism and the effects of GABA on the nutrient content of edamame seeds through physiological and metabolomic analyses. Exogenous GABA increased endogenous GABA metabolism and GABA transaminase activity and enhanced the oxoglutarate content, which entered into nitrogen metabolism and increased the activity and expression of nitrogen metabolism-related enzymes, to accumulate AAs and bioactive peptides. Meanwhile, exogenous GABA induced the metabolism of flavonoids, including total flavonoids, anthocyanins, 6''-o-malonyglycitin, glycitin, ononin, cyanin, and ginkgetin, by increasing the activity and expression of flavonoid biosynthetic enzymes. This is the first study to reveal that GABA effectively improves the nutritional quality of edamame through the accumulation of AAs, bioactive peptides, isoflavones, anthocyanins, sugars, and organic acids.

Indexed as

4CL, 4-coumarate coenzyme A ligaseANS, anthocyanidin synthaseC4H, cinnamic acid 4-hydroxylaseCHI, chalcone isomeraseCHS, chalcone synthaseDFR, dihydroflavanol 4-reductaseEdamameF3′H, flavanone 3′-hydroxylaseF3H, flavanone 3-hydroxylaseFlavonoid metabolismGABA-T, γ-aminobutyric acid transferaseGABA, γ-aminobutyric acidGAD, glutamate decarboxylaseGDH, glutamate dehydrogenaseGOGAT, glutamate synthaseGOT, glutamic-oxaloacetic transaminaseGPT, glutamic-pyruvic transaminaseGR, glutathione reductaseGS, glutamine synthetaseGSH, glutathioneIFS, isoflavone synthaseNitrogen metabolismNR, nitrate reductaseNutritional qualityPAL, phenylalanine ammonia-lyaseTCA cycle, tricarboxylic acid cycleUFGT, UDP-glycose flavonoid glycosyltransferaseVc, vitamin Cγ-Aminobutyric acidγ-ECS, γ-glutamylcysteine synthetase

Identifiers

PMID36519087
PMCPMC9743267
OpenAlexW4309341359

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.