Evidence map›Paper›PMID 36519059›Full record

ArticleChemical science2022

Amphiphilic stilbene derivatives attenuate the neurotoxicity of soluble Aβ

Zhengxin Yu, Weijie Guo, Shrey Patel, Hong-Jun Cho, Liang Sun, Liviu M Mirica

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Multivalent Neuroprotective Activity ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhengxin YuDepartment of Chemistry, Beckman Institute for Advanced Science and Technology, The Neuroscience Program, University of Illinois at Urbana-Champaign 600 S. Mathews Avenue Urbana Illinois 61801 USA mirica@illinois.edu.ORCID https://orcid.org/0000-0002-3592-9704
Weijie GuoDepartment of Biochemistry, University of Illinois at Urbana-Champaign 600 S. Mathews Avenue Urbana Illinois 61801 USA.ORCID https://orcid.org/0000-0001-5694-2142
Shrey PatelDepartment of Chemistry, Beckman Institute for Advanced Science and Technology, The Neuroscience Program, University of Illinois at Urbana-Champaign 600 S. Mathews Avenue Urbana Illinois 61801 USA mirica@illinois.edu.
Hong-Jun ChoDepartment of Chemistry, Beckman Institute for Advanced Science and Technology, The Neuroscience Program, University of Illinois at Urbana-Champaign 600 S. Mathews Avenue Urbana Illinois 61801 USA mirica@illinois.edu.
Liang SunDepartment of Chemistry, Beckman Institute for Advanced Science and Technology, The Neuroscience Program, University of Illinois at Urbana-Champaign 600 S. Mathews Avenue Urbana Illinois 61801 USA mirica@illinois.edu.
Liviu M MiricaDepartment of Chemistry, Beckman Institute for Advanced Science and Technology, The Neuroscience Program, University of Illinois at Urbana-Champaign 600 S. Mathews Avenue Urbana Illinois 61801 USA mirica@illinois.edu.ORCID https://orcid.org/0000-0003-0584-9508
University of Illinois Urbana-Champaign · US

Funding

NOVEL BIFUNCTIONAL CHEMICAL AGENTS AS THERANOSTIC TOOLS FOR AMYLOID DISEASESR01GM114588 · NIGMS · WASHINGTON UNIVERSITY · PI MIRICA, LIVIU M. · 2015 to 2019
$1.4M
NIGMS NIH HHS R01 GM114588
6 · The paper itself

Abstract

The misfolded proteins or polypeptides commonly observed in neurodegenerative diseases, including Alzheimer's disease (AD), are promising drug targets for developing therapeutic agents. To target the amyloid-β (Aβ) peptide plaques and oligomers, the hallmarks of AD, we have developed twelve amphiphilic small molecules with different hydrophobic and hydrophilic fragments.

Identifiers

PMID36519059
PMCPMC9645390
OpenAlexW4311826103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.