Evidence map›Paper›PMID 36518878›Full record

ReviewBurns & trauma2022

Hydrogels for the management of second-degree burns: currently available options and future promise.

Katherine A Cook, Edith Martinez-Lozano, Robert Sheridan, Edward K Rodriguez, Ara Nazarian, Mark W Grinstaff

Open access · diamondAbstract readReview
In one paragraph

Review in Burns & trauma, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Chitosan hydrogels loaded with CuScientific reports · 2025
    Article
  13. Article
  14. Article
  15. The Effects ofAdvanced biomedical research · 2024
    Article
  16. Rational Design of Multifunctional Hydrogels for Wound Repair.Journal of functional biomaterials · 2023
    Review
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Katherine A CookDepartment of Chemistry, Biomedical Engineering, and Medicine, Boston University, Boston, MA, 02215, USA.
Edith Martinez-LozanoMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Robert SheridanShriners Hospitals for Children and Burns Service, Department of Surgery, Massachusetts General Hospital, Boston, MA, 02214, USA.
Edward K RodriguezMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Ara NazarianMusculoskeletal Translational Innovation Initiative, Carl J. Shapiro, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Mark W GrinstaffDepartment of Chemistry, Biomedical Engineering, and Medicine, Boston University, Boston, MA, 02215, USA.ORCID https://orcid.org/0000-0002-5453-3668
Beth Israel Deaconess Medical Center · USBoston University · USMassachusetts General Hospital · US

Funding

Dissolvable Hydrogel Dressing for the Treatment of BurnsR01EB021308 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI GRINSTAFF, MARK W., NAZARIAN, ARA · 2016 to 2019
$1.5M
NIBIB NIH HHS R01 EB021308
6 · The paper itself

Abstract

Burn wounds result from exposure to hot liquids, chemicals, fire, electric discharge or radiation. Wound severity ranges from first-degree injury, which is superficial, to fourth-degree injury, which exposes bone, tendons and muscles. Rapid assessment of burn depth and accurate wound management in the outpatient setting is critical to prevent injury progression into deeper layers of the dermis. Injury progression is of particular pertinence to second-degree burns, which are the most common form of thermal burn. As our understanding of wound healing advances, treatment options and technologies for second-degree burn management also evolve. Polymeric hydrogels are a class of burn wound dressings that adhere to tissue, absorb wound exudate, protect from the environment, can be transparent facilitating serial wound evaluation and, in some cases, enable facile removal for dressing changes. This review briefly describes the burn level classification and common, commercially available dressings used to treat second-degree burns, and then focuses on new polymeric hydrogel burn dressings under preclinical development analyzing their design, structure and performance. The review presents the follow key learning points: (1) introduction to the integument system and the wound-healing process; (2) classification of burns according to severity and clinical appearance; (3) available dressings currently used for second-degree burns; (4) introduction to hydrogels and their preparation and characterization techniques; and (5) pre-clinical hydrogel burn wound dressings currently being developed.

Indexed as

BurnDressingHydrogelSecond-degreeWound

Identifiers

PMID36518878
PMCPMC9733594
OpenAlexW4311824266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.