Evidence map›Paper›PMID 36518792›Full record

ArticleTransplantation direct2023

Range and Consistency of Cardiovascular Outcomes Reported by Clinical Trials in Kidney Transplant Recipients: A Systematic Review.

Gregory J Wilson, Kim Van, Emma O'Lone, Allison Tong, Jonathan C Craig, Benedicte Sautenet, Klemens Budde, Derek Forfang, John Gill, William G Herrington and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 11 institutions in 7 countries.

Gregory J WilsonFaculty of Medicine, University of Queensland, Brisbane, QLD, Australia.
Kim VanSydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Emma O'LoneSydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Allison TongSydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Jonathan C CraigCollege of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Benedicte SautenetService de Nephrologie-Hypertension, Dialyses, Transplantation Rénale, Hopital Bretonneau, Université de Tours, Université de Nantes, INSERM SPHERE U 1246, Tours, France.
Klemens BuddeCharité Universitätsmedizin Berlin, Berlin, Germany.
Derek ForfangNational Kidney Foundation, New York, NY.
John GillUniversity of British Columbia, Vancouver, BC, Canada.
William G HerringtonNuffield Department of Population Health, Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom.
Tazeen H JafarDuke - NUS Medical School, Singapore, Singapore.
David W JohnsonFaculty of Medicine, University of Queensland, Brisbane, QLD, Australia.
Vera KraneUniversity of Würzburg, Würzburg, Germany.
Adeera LevinUniversity of British Columbia, Vancouver, BC, Canada.
Jolanta MalyszkoDepartment of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany.
Patrick RossignolUniversité de Lorraine & FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists) Network, Nancy, France.
Deirdre SawinskiWeill Cornell Medical College, New York, NY.
Nicole Scholes-RobertonsThe University of Sydney, Sydney, NSW, Australia.
Giovanni StrippoliUniversity of Bari, Bari, Italy.
Angela WangThe University of Hong Kong, Pok Fu Lam, Hong Kong.
Wolfgang C WinkelmayerBaylor College of Medicine, Houston, TX.
Carmel M HawleyFaculty of Medicine, University of Queensland, Brisbane, QLD, Australia.
Andrea K ViecelliFaculty of Medicine, University of Queensland, Brisbane, QLD, Australia.
The University of Queensland · AUThe University of Sydney · AUFlinders University · AUUniversity of British Columbia · CABaylor College of Medicine · USCharité - Universitätsmedizin Berlin · DEDuke-NUS Medical School · SGNational Kidney Foundation · USPrincess Alexandra Hospital · AUUniversity of Bari Aldo Moro · ITUniversity of Würzburg · DE

Funding

Medical Research Council MC_UU_00017/3Medical Research Council MR/N006178/1
6 · The paper itself

Abstract

Cardiovascular disease is a major cause of morbidity and mortality in kidney transplant recipients. Trial evidence to improve cardiovascular outcomes is limited by inconsistent reporting of outcomes, which may also lack patient-relevance. This study aimed to assess the range and consistency of cardiovascular outcomes reported by contemporary trials in kidney transplant recipients. Methods: A systematic review of all randomized controlled trials involving adult kidney transplant recipients that reported at least 1 cardiovascular outcome from January 2012 to December 2019 was performed, including Embase, MEDLINE, Cochrane, and ClinicalTrials.gov electronic databases. Trial characteristics were extracted and all levels of specification of the cardiovascular outcome measures reported were analyzed (the measure definition, metric' and method of aggregation). Measures assessing a similar aspect of cardiovascular disease were categorized into outcomes. Results: From 93 eligible trials involving 27 609 participants, 490 outcome measures were identified. The outcome measures were grouped into 38 outcomes. A cardiovascular composite was the most common outcome reported (40 trials, 43%) followed by cardiovascular mortality (42%) and acute coronary syndrome (31%). Cardiovascular composite was also the most heterogeneous outcome with 77 measures reported followed by cardiovascular mortality (n = 58) and inflammatory biomarkers (n = 51). The most common cardiovascular composite outcome components reported were major cardiovascular events (18 trials), stroke unspecified (11 trials), and myocardial infarction unspecified (10 trials). Conclusions: There is substantial heterogeneity in cardiovascular outcome reporting in kidney transplant trials.

Identifiers

PMID36518792
PMCPMC9742089
OpenAlexW4311274785

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.