ArticleFrontiers in public health2022
Cognitive impairment assessed by Mini-Mental State Examination predicts all-cause and CVD mortality in Chinese older adults: A 10-year follow-up study.
Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Association of low sleep efficiency and carotid plaque with cognitive impairment in older adults with chronic diseases: A retrospective cross-sectional study.The Journal of international medical research · 2026Article
- Prevalence and Severity of Cognitive Impairment Among Older Adults Using Benzodiazepines in Primary Care: Association with Duration of Use and Prescribing Pattern in Mexico.Healthcare (Basel, Switzerland) · 2026Article
- The association between cognitive function trajectories and all-cause mortality in middle-aged and older Chinese adults with cardiovascular disease: A longitudinal study from CHARLS.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Cognitive decline and risk of all-cause mortality in older women: a cohort study.BMC geriatrics · 2026Article
- Analysis of Spatiotemporal Features in a Virtual Navigation Game Across Different Age Groups: Quantitative Research.JMIR serious games · 2026Article
- Effect of hearing ability on inflammation and glymphatic function affecting cognition in older adults.GeroScience · 2026Observational
- The Link Between Physical Fitness and Cognitive Function in Vulnerable Low-Income Older Adults from Amazonas, Brazil.Healthcare (Basel, Switzerland) · 2026Article
- Association between psychological resilience and global health status/quality of life in patients with brain metastases after resection of primary non-small cell lung cancer.Frontiers in psychiatry · 2026Article
- Examining the Impact of Natural Teeth Trajectory on Mortality Among CLHLS.International dental journal · 2025Article
- Association between physical activity and cognitive function in post-menopausal women with high parity: the chain-mediating effects of nutritional status and depression.BMC women's health · 2025Article
- Impact of Combined Cognitive and Physical Impairments on Long-Term Prognosis in Elderly Cardiovascular Disease Patients: A Prospective Cohort Study.Clinical interventions in aging · 2025Article
- Preoperative mild cognitive impairment as a risk factor of postoperative cognitive dysfunction in elderly patients undergoing spine surgery.Frontiers in aging neuroscience · 2024Article
- Handgrip strength is associated with mortality in community-dwelling older adults: the Yilan cohort study, Taiwan.BMC public health · 2023Article
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17 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: Cognitive impairment (CI) has been demonstrated as a useful proxy measure of mortality in Western populations. However, the predictive value of CI in Chinese populations is unknown. We aimed to explore whether CI is independently associated with increased long-term all-cause and cardiovascular disease (CVD) mortality in Chinese older adults and the association of performance in specific MMSE sub-domains to subsequent mortality. Methods and results: A total of 4,499 older adults [mean (SD) age, 70.3(6.7) years] who received a sample investigation from 2011 to 2014 were followed up till 2021 for mortality. The Mini-Mental State Examination was used to assess cognitive function, and Cox's proportional hazard models were used to evaluate the effects of cognitive function on the risk of all-cause and CVD mortality. Demographic characteristics, lifestyle, and health status were included as covariates. During a 10-year follow-up, a total of 667 (14.8%) died. In the fully adjusted model, compared with cognitively normal participants with CI had a 1.33-fold [HR, 1.33; (95% CI, 1.10-1.61)] greater risk of all-cause mortality and a 1.45-fold [HR, 1.45; (95% CIs, 1.11-1.92)] greater risk of CVD mortality. After a similar multivariable adjustment, a per-SD increase in MMSE scores was associated with a reduced risk of all-cause mortality [HR, 0.85; (95% CI, 0.78-0.93)] and CVD mortality [HR, 0.74; (95% CI, 0.65-0.84)]. In the unadjusted model, MMSE sub-domains (apart from immediate recall) were associated with mortality. But only orientation and calculation and attention were still independently associated with all-cause and CVD mortality in a multivariable model. Conclusion: These findings confirmed that CI is a marker of all-cause and CVD mortality risk in Chinese older adults, independently of other commonly assessed risk factors, and some sub-domains of the MMSE may have stronger associations with mortality. Further research is needed to identify the mechanisms underlying the observed associations.
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