Evidence map›Paper›PMID 36518483›Full record

ArticleToxicology reports2022

Inhibitory effects of Thai herbal extracts on the cytochrome P450 3A-mediated the metabolism of gefitinib, lapatinib and sorafenib.

Chumaphorn Rodseeda, Paveena Yamanont, Darawan Pinthong, Porntipa Korprasertthaworn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Recent Advances in the Use ofPharmaceutics · 2025
    Review
  3. Review
  4. Ganodermataceae-current status, research, and development in Lower Mekong Basin.Frontiers in cellular and infection microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chumaphorn RodseedaGraduate Program in Toxicology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Paveena YamanontDepartment of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Darawan PinthongDepartment of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Porntipa KorprasertthawornGraduate Program in Toxicology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Mahidol University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herbal products are widely used in cancer patients via co-administration with chemotherapy. Previous studies have demonstrated that pharmacokinetic interactions between herbs and anticancer drugs exist due to inhibition of drug-metabolizing enzymes, particularly cytochrome P450s (CYPs). The aim of this study was to determine the inhibitory effects of

Indexed as

ATP, adenosine 5′ triphosphateCYP, cytochrome P450Cytochrome P450 3ADMSO, dimethyl sulfoxideDrug−herb interactionEGFR, epidermal growth factor receptorFDA, Food and Drug AdministrationG−6−PD, G−6−P dehydrogenaseG−6−P, glucose−6−phosphateGEF, gefitinibHER2, human epidermal growth factor receptor 2Herbal extractHLM, human liver microsomeHPLC, high-performance liquid chromatographyIC50, half maximal inhibitory concentrationKi, inhibition constantLC/MS, liquid mass spectrometryNADP, nicotinamide adenine dinucleotide phosphatePDGFR, platelet−derived growth factor receptorRAF, Rapidly Accelerated FibrosarcomaSOR, sorafenibTKI, tyrosine kinase inhibitorTyrosine kinase inhibitorUGT, UDP-glucuronosyltransferaseUV, ultravioletVEGFR, vascular endothelial growth factor receptor

Identifiers

PMID36518483
PMCPMC9742957
OpenAlexW4300860253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.